Ever Young Additional Information


Ingredient Supporting Studies:

  1. McFarland, G.A., R. Holliday. "Retardation of the Senescence of Cultured Human Diploid Fibroblasts by Carnosine." Exp Cell Res 212:2 (1994): 167--175. <http://www.ncbi.nlm.nih.gov/pubmed/8187813>
  2. McFarland, G.A., R. Holliday. "Further Evidence for the Rejuvenating Effects of the Dipeptide L-Carnosine on Cultured Human Diploid Fibroblasts." Exp Gerontol 34:1 (1999): 35--45. <http://www.ncbi.nlm.nih.gov/pubmed/10197726>
  3. Yuneva, M.O., E.R. Bulygina, S.C. Gallant, et al. "Effect of Carnosine on Age induced Changes in Senescence-accelerated Mice." J Anti-Aging Med 2:4 (1999):  337--342. <http://online.liebertpub.com/doi/abs/10.1089/rej.1.1999.2.337>
  4. Boldyrev, A., R. Song, D. Lawrence, et al. "Carnosine Protects Against Excitotoxic Cell Death Independently of Effects on Reactive Oxygen Species." Neuroscience 94:2 (1999): 571--577. <http://www.ncbi.nlm.nih.gov/pubmed/10579217>
  5. Hipkiss, A.R., C. Brownson. "A Possible New Role for the Anti-ageing Peptide Carnosine." Cell Mol Life Sci 57:5 (2000): 747--753. <http://www.ncbi.nlm.nih.gov/pubmed/10892341>
  6. Asif, M., J. Egan, S. Vasan, et al. "An Advanced Glycation Endproduct Cross-link Breaker Can Reverse Age-related Increases in Myocardial Stiffness." Proc Natl Acad Sci USA 97:6 (March 2000): 2809--2813. <http://www.ncbi.nlm.nih.gov/pubmed/10706607>
  7. Liu, J., M.R. Masurekar, D.E. Vatner, et al. "Glycation End-product Cross-link Breaker Reduces Collagen and Improves Cardiac Function in Aging Diabetic Heart." Am J Physiol Heart Circ Physiol 285:6 (December 2003): H2587--H2591. <http://www.ncbi.nlm.nih.gov/pubmed/12946933>
  8. Preston, J.E., A.R. Hipkiss, D.T. Himsworth, et al. "Toxic Effects of Beta-amyloid(25-35) on Immortalised Rat Brain Endothelial Cell: Protection by Carnosine, Homocarnosine and Beta-alanine." Neurosci Lett 242:2 (February 1998): 105--108. <http://www.ncbi.nlm.nih.gov/pubmed/9533405>
  9. Dennis J. Selkoe "Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid ß-protein." Journal of Alzheimer's Disease. Volume 3, Number 1, February 2001 75-81. <http://www.j-alz.com/issues/3/3(1)/selkoe_p75.pdf>
  10. Quinn, P., A.A. Boldyrev, et al. "Carnosine: Its Properties, Functions and Potential Therapeutic Applications." Molec Aspects Med 13 (1992): 379--444. <http://www.ncbi.nlm.nih.gov/pubmed/9765790>
  11. Quinn. Carnosine: Its Properties
  12. Rosick, Edward R. "How Carnosine Protects Against Age-Related Disease." Life  Extension Magazine (January 2006). <www.lef.org/magazine/mag 2006/jan2006_report_carnosine_02.htm.>
  13. Wu XH, Ding MP, Zhu-Ge ZB, et al. "Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat." Neurosci Lett. 2006 May 29;400(1-2):146-9. Epub 2006 Mar 3. <http://www.ncbi.nlm.nih.gov/pubmed/16515835>
  14. Stvolinsky S, Antipin M, Meguro K, Sato T, Abe H, Boldyrev A. "Effect of carnosine and its Trolox-modified derivatives on life span of Drosophila melanogaster." Rejuvenation Res. 2010 Aug;13(4):453-7. <http://www.ncbi.nlm.nih.gov/pubmed/20681748>
  15. Nagai K, Tanida M, Niijima A, et al. "Role of L: -carnosine in the control of blood glucose, blood pressure, thermogenesis, and lipolysis by autonomic nerves in rats: involvement of the circadian clock and histamine." Amino Acids. 2012 Jul;43(1):97-109. Epub 2012 Feb 25. <http://www.ncbi.nlm.nih.gov/pubmed/22367578>
  16. McFarland. Retardation.
  17. Kilis-Pstrusinska K. "Carnosine, carnosinase and kidney diseases." Postepy Hig Med Dosw (Online). 2012 Apr 20;66:215-23. <http://www.phmd.pl/fulltxt.php?ICID=991600>
  18. Janssen B, Hohenadel D, Brinkkoetter P, et al. "Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1." Diabetes. 2005 Aug;54(8):2320-7. <http://www.ncbi.nlm.nih.gov/pubmed/16046297>
  19. Francesco Attanasio, Sebastiano Cataldo, et al. "Protective Effects of l- and d-Carnosine on a-Crystallin Amyloid Fibril Formation: Implications for Cataract Disease." Biochemistry, 2009, 48 (27), pp 6522--6531 <http://www.ncbi.nlm.nih.gov/pubmed/19441807>
  20. Sibylle Sauerho, Gang Yuan, Gerald Stefan Braun. "L-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism." Diabetes October 2007 56:2425-2432 <http://diabetes.diabetesjournals.org/content/56/10/2425.full.pdf>
  21. Rashid I, van Reyk DM, Davies MJ. "Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro." FEBS Lett. 2007 Mar 6;581(5):1067-70. <http://www.ncbi.nlm.nih.gov/pubmed/17316626>
  22. Stvolinsky SL, Dobrota D. "Anti-ischemic activity of carnosine. Biochemistry (Mosc)". 2000 Jul;65(7):849-55. <http://www.ncbi.nlm.nih.gov/pubmed/9113734>
  23. Zaloga GP, Roberts PR, Black KW, et al. "Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells." Am J Physiol. 1997;272(1 Pt 2):H462-8.  <http://www.ncbi.nlm.nih.gov/pubmed/9038968>
  24. Ansurudeen I, Sunkari VG, Grünler J, et al."Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes." Amino Acids. 2012 Jul;43(1):127-34. Epub 2012 Mar 24. <http://www.ncbi.nlm.nih.gov/pubmed/22451275>
  25. Naghshvar F, Abianeh SM, Ahmadashrafi S, Hosseinimehr SJ. "Chemoprotective effects of carnosine against genotoxicity induced by cyclophosphamide in mice bone marrow cells."Cell Biochem Funct. 2012 Apr 26. <http://www.ncbi.nlm.nih.gov/pubmed/22535690>
  26. Hyland P, Duggan O, Hipkiss A, Barnett C, Barnett Y. "The effects of carnosine on oxidative DNA damage levels and in vitro life span in human peripheral blood derived CD4+T cell clones." Mech Ageing Dev. 2000 Dec 20;121(1-3):203-15. <http://www.ncbi.nlm.nih.gov/pubmed/11164474>
  27. Renner C, Zemitzsch N, Fuchs B, et al. "Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model." Mol Cancer. 2010;9:2. <http://www.ncbi.nlm.nih.gov/pubmed/20053283>
  28. Chuang CH, Hu ML. "L-carnosine inhibits metastasis of SK-Hep-1 cells by inhibition of matrix metaoproteinase-9 expression and induction of an antimetastatic gene, nm23-H1." Nutr Cancer. 2008;60(4):526-33. <http://www.ncbi.nlm.nih.gov/pubmed/18584487>
  29. Baykara B, Cilaker Micili S, Tugyan K. "The protective effects of carnosine in alcohol-induced hepatic injury in rats."Toxicol Ind Health. 2012 Jun 1. <http://www.ncbi.nlm.nih.gov/pubmed/22661399>
  30. Ron Kohen, Yorihiro Yamamoto, Kenneth C. Cundy, Bruce N. Ames. "Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain." Proc. NatI. Acad. Sci. USA Vol. 85, pp. 3175-3179, May 1988. <http://www.pnas.org/content/85/9/3175.full.pdf>
  31. Fleisher-Berkovich S, Abramovitch-Dahan C, Ben-Shabat S, Apte R, Beit-Yannai E. "Inhibitory effect of carnosine and N-acetyl carnosine on LPS-induced microglial oxidative stress and inflammation." Peptides. 2009 Jul;30(7):1306-12. Epub 2009 Apr 10. <http://www.ncbi.nlm.nih.gov/pubmed/19540429>
  32. Charles Eric. Brown, William E. Antholine. "Chelation chemistry of carnosine. Evidence that mixed complexes may occur in vivo." J. Phys. Chem., 1979, 83 (26), pp 3314--3319. <http://pubs.acs.org/doi/abs/10.1021/j100489a002>
  33. Fonteh AN, Harrington RJ, Tsai A, Liao P, Harrington MG. "Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects." Amino Acids. 2007 Feb;32(2):213-24. <http://www.ncbi.nlm.nih.gov/pubmed/17031479>
  34. Hipkiss AR. "Could carnosine or related structures suppress Alzheimer's disease?" J Alzheimers Dis. 2007 May;11(2):229-40. <http://www.ncbi.nlm.nih.gov/pubmed/17522447>
  35. Tsai SJ, Kuo WW, Liu WH, Yin MC. "Antioxidative and anti-inflammatory protection from carnosine in the striatum of MPTP-treated mice." J Agric Food Chem. 2010 Oct 6. <http://www.ncbi.nlm.nih.gov/pubmed/20925384>