pHi-Zymes Additional Information


Ingredient Supporting Studies:

  1. Hedstrom, L. (Dec 2002). "Serine protease mechanism and specificity." Chem Rev 102 (12): 4501--24.
  2. Chapman HA, Riese RJ, Shi GP (1997). "Emerging roles for cysteine proteases in human biology." Annu. Rev. Physiol. 59: 63--88.
  3. Arazi A1, Neumann AU. "Modeling immune complex-mediated autoimmune inflammation." J Theor Biol. 2010 Dec 7;267(3):426-36.
  4. P O Cano, L M Jerry, J P Sladowski, and C K Osterland. "Circulating immune complexes in systemic lupus erythematosus." Clin Exp Immunol. Aug 1977; 29(2): 197--204.
  5. tauder G, Ransberger K, Streichhan P, Van Schaik W, Pollinger W. "The use of hydrolytic enzymes as adjuvant therapy in AIDS/ARC/LAS patients." Biomed Pharmacother. 1988;42(1):31-4.
  6. Cecil Adams. "Is it aerodynamically impossible for bumblebees to fly?" The Straight Dope. May 4, 1990. (Accessed 24 Jun 2014.)
  7. Brad Rachman, "Unique Features and Application of Non-Animal Derived Enzymes." Clinical Nutrition Insights. 510 8/97 Vol. 5, No. 10. (Accessed 24 Jun 2014.)
  8. Laura P. Hale. "Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice." International Immunopharmacology. Volume 4, Issue 2, February 2004, Pages 255--264.
  9. KOLAC C., STREICHHAN P., LEHR C.-M. "Oral bioavailability of proteolytic enzymes." European journal of pharmaceutics and biopharmaceutics. 1996, vol. 42, no4, pp. 222-232 (68 ref.)
  12. Stauder G. "Pharmacological effects of oral enzyme combinations." Cas Lek Cesk. 1995 Oct 4;134(19):620-4.
  13. Nouza K. "Systemic enzyme therapy in diseases of the vascular system." Bratisl Lek Listy. 1995 Oct;96(10):566-9.
  14. Beuth J. "Proteolytic enzyme therapy in evidence-based complementary oncology: fact or fiction?" Integr Cancer Ther. 2008 Dec;7(4):311-6. doi: 10.1177/1534735408327251.
  15. Desser L, Rehberger A, Paukovits W. "Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro." Cancer Biother 1994;9:253-63.
  16. Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. "Bromelain treatment decreases neutrophil migration to sites of inflammation." Clin Immunol. 2008 Jul;128(1):66-74.
  17. Tassman G, Zafran J, Zayon G. "A double-blind crossover study of a plant proteolytic enzyme in oral surgery." J Dent Med 1965;20:51--4.
  18. Cirelli MG. "Treatment of inflammation and edema with bromelain." Delaware Med J 1962;34:159--67.
  19. Brien S, Lewith G, Walker A, Hicks SM, Middleton D. "Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies." Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257.
  20. Akhtar NM1, Naseer R, Farooqi AZ, Aziz W, Nazir M. "Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study." Clin Rheumatol. 2004 Oct;23(5):410-5.
  21. Heinicke R, van der Wal L, Yokoyama M. "Effect of bromelain (Ananase) on human platelet aggregation." Experientia 1972;28:844--5.
  22. Juhasz B, Thirunavukkarasu M, Pant R, Zhan L, Penumathsa SV, et al. "Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium." Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1365-70.
  23. Rakhimov MR. "Anti-inflammatory activity of domestic papain]." Eksp Klin Farmakol. 2001 Jul-Aug;64(4):48-9.
  24. Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S.  "Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan." Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347.
  25. Murakami K1, Yamanaka N, Ohnishi K, Fukayama M, Yoshino M. "Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese traditional fermented food." Food Funct. 2012 Jun;3(6):674-8.
  26. Kim JY, Gum SN, Paik JK, et al. "Effects of nattokinase on blood pressure: a randomized, controlled trial." Hypertens Res. 2008;31(8):1583-1588.
  27. Fossati A. "Anti-inflammatory effects of seaprose-S on various inflammation models."  Drugs Exp Clin Res. 1999;25(6):263-70.
  28. Moretti M, Bertoli E, Bulgarelli S, Testoni C, et al. "Effects of seaprose on sputum biochemical components in chronic bronchitic patients: a double-blind study vs placebo." Int J Clin Pharmacol Res. 1993;13(5):275-80.
  29. raga PC, Rampoldi C et al "In vitro rheological assessment of mucolytic activity induced by seaprose." Pharmacol Res 1990;22(5):611-617.
  30. Bracale G, Selvetella L. "Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase." Minerva Cardioangiol. 1996 Oct;44(10):515-24.
  31. Bracale.
  32. Kuzan A1, Chwilkowska A, Kobielarz M, Pezowicz C, Gamian A. "Glycation of extracellular matrix proteins and its role in atherosclerosis. Postepy Hig Med Dosw (Online). 2012 Oct 29;66:804-9.
  33. James Couch. "Rutin for Capillaries. USDA Yearbook of Agriculture. 1947 p711.
  34. Teresita Guardia, Alejandra Ester Rotelli, et al. "Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat." Il Farmaco Volume 56, Issue 9, 1 August 2001, Pages 683--687.
  35. Selloum L1, Bouriche H, Tigrine C, Boudoukha C. "Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation." Exp Toxicol Pathol. 2003 Mar;54(4):313-8.
  36. Drewa G, Schachtschabel DO, Palgan K, et al. "The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice." Neoplasma 1998;45:266-71.
  37. Webster RP, Gawde MD, Bhattacharya RK. "Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats." Cancer Lett 1996;109:185-91.
  38. Reema Jasuja, Freda H. Passam, Daniel R. Kennedy, Robert Flaumenhaft, et al. "Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents." J Clin Invest. 2012; 122(6):2104--2113.
  39. El-Akabawy G, El-Kholy W. "Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats." Ann Anat. 2014 May;196(2-3):119-28.
  40. Yang M, Liu C, Jiang J, Zuo G, Lin X, et al. "Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats." BMC Complement Altern Med. 2014 May 27;14(1):174.
  41. Moon M, Kim HG, Choi JG, Oh H, et al. "6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia." Biochem Biophys Res Commun. 2014 Jun 20;449(1):8-13.
  42. Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. "Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats." Rejuvenation Res. 2013 Apr;16(2):124-33.
  43. Duskova M, Wald M. "Orally administered proteases in aesthetic surgery." Aesthetic Plast Surg. 1999 Jan;23(1):41-4.