Triple Jointed Additional Information


Ingredient Supporting Studies:

  1. Christelle Sanchez, Michelle A Deberg, Nathalie Piccardi, et al. "Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes." J Rheumatol August 2003 30(8):1825-1834.
  2. Appelboom T, Schuermans J, et al. "Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study." Scand J Rheumatol. 2001;30(4):242-7.
  3. Maheu E, Cadet C, Marty M, Moyse D, et al. "Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study." Ann Rheum Dis. 2014 Feb;73(2):376-84.
  4. 4Andriamanalijaona R, Benateau H, et al. "Effect of interleukin-1beta on transforming growth factor-beta and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture: modulation by avocado and soybean unsaponifiables." J Periodontol. 2006 Jul;77(7):1156-66.
  5. Kut-Lasserre C, Miller CC, Ejeil AL, et al. "Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (TIMP- 1 and TIMP-2) secretion by human fibroblasts in culture." J Periodontol. 2001 Dec;72(12):1685-94.
  6. Kut C, Assoumou A, Dridi M, et al. "Morphometric analysis of human gingival elastic fibres degradation by human leukocyte elastase protective effect of avocado and soybean unsaponifiables (ASU)." Pathol Biol (Paris). 1998 Sep;46(7):571-6.
  7. Bagchi D, Misner B, Bagchi M, et al. "Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration." Int J Clin Pharmacol Res. 2002;22(3-4):101-10.
  8. David C. Crowley, Francis C. Lau, et al. "Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial." Int J Med Sci. 2009; 6(6): 312--321.
  9. Bagchi
  10. Trentham, RA Dynesius-Trentham, et al., "Effects of Oral Administration of Type II collagen on Rheumatoid Arthritis." Science, 261:1727-1730, 1993.
  11. "Celebrex, Vioxx and Bextra News." Consumer Affairs. (Accessed 11 May 2015.)
  12. Srivastava KC, Mustafa T. "Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders." Med Hypotheses. 1992 Dec;39(4):342-8.
  13. Altman RD, Marcussen KC. "Effects of a ginger extract on knee pain in patients with osteoarthritis." Arthritis Rheum. 2001 Nov;44(11):2531-8.
  14. Srivastava
  15. Wigler I, Grotto I, Caspi D, Yaron M. "The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis." Osteoarthritis and Cartilage November 2003 Volume 11, Issue 11, Pages 783--789.
  16. El-Akabawy G, El-Kholy W. "Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats." Ann Anat. 2014 May;196(2-3):119-28.
  17. Yang M, Liu C, Jiang J, Zuo G, Lin X, et al. "Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats." BMC Complement Altern Med. 2014 May 27;14(1):174.
  18. Moon M, Kim HG, Choi JG, Oh H, et al. "6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia." Biochem Biophys Res Commun. 2014 Jun 20;449(1):8-13.
  19. Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. "Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats." Rejuvenation Res. 2013 Apr;16(2):124-33.
  20. Diehl HW, May EL. "Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats." J Pharm Sci. 1994 Mar;83(3):296-9.
  21. H. Siemandi, et al. "The Effect of cis-9-Cetyl Myristoleate (CMO) and Adjunctive Therapy on Arthritis and Auto-Immune Disease: A Randomized Trial. The Townsend Letter for Doctors and Patients. Aug 1997;169/170: 58-63
  22. Hesslink R, Jr, Armstrong D, III, et al. "Cetylated fatty acids improve knee function in patients with osteoarthritis." J Rheumatol. 2002;29:1708--1712.
  23. Hunter KW, Jr. Gault RA, Stehouwer JS, Tam-Chang SW. "Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis." Pharmacol Res. 2003 Jan;47(1):43-7.
  24. Umar S, Umar K, Sarwar AH, et al. "Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis." Phytomedicine. 2014 May 15;21(6):847-56.
  25. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M. "Frankincense ( ru xiang; boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases." J Tradit Complement Med. 2013 Oct;3(4):221-6.
  26. Togni S, Maramaldi G, et al. "A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis." Clin Cosmet Investig Dermatol. 2014 Nov 11;7:321-7.
  27. Gupta PK, Samarakoon SM, et al. "Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis)." Ayu. 2011 Oct;32(4):478-82.
  28. Ammon HP. "Modulation of the immune system by boswellia serrata extracts and boswellic acids." Phytomedicine. 2010 Sep;17(11):862-7. Epub 2010 Aug 8.
  29. Reichling J, Schmökel H, Fitzi J, et al. "Dietary support with Boswellia resin in canine inflammatory joint and spinal disease." Schweiz Arch Tierheilkd. 2004 Feb;146(2):71-9.
  30. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. "Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial." Phytomedicine. 2003 Jan;10(1):3-7.
  31. Gupta I, Gupta V, Parihar A, et al. "Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study." Eur J Med Res. 1998 Nov 17;3(11):511-4.
  32. Gerhardt H, Seifert F, Buvari P, et al. "[Therapy of active Crohn disease with Boswellia serrata extract H 15]." Z Gastroenterol. 2001 Jan;39(1):11-7.
  33. Roy S, Khanna S, Krishnaraju AV, et al. "Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia." Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):653-60.
  34. Ammon HP. "Boswellic acids in chronic inflammatory diseases." Planta Med. 2006 Oct;72(12):1100-16.