Ultimate Antioxidant™

Looking for the ultimate full spectrum blend of natural antioxidants to help with free radicals? Baseline Nutritionals'® Ultimate Antioxidant™ provides full doses of 21 synergistic powerful antioxidants. Potent Full Spectrum Formula of Natural Antioxidants:

  • Full doses of 21 synergistic & powerful natural antioxidants including Green Tea, Resveratrol, Lycopene, Bilberry, Quercetin, R. Lipoic Acid, and OPCs!
  • Nature's ultimate defense against premature aging, age related challenges, and a compromised immune system
  • Helps neutralize free radicals that can “eat away” major organs of the body
  • Incorporates full-complex alpha and beta carotene
  • Promotes healthy cell growth throughout body
In stock
100% of 100

Discount Club

Get Members Only
Exclusive Coupons!
Sign Up for Monthly Specials

The link between free radicals (caused by cigarette smoke, air pollution, pesticides, radiation, stress, rancid oils, etc.) and aging challenges is the most important discovery since doctors learned that some illnesses are caused by germs. Antioxidants are compounds that render free radicals harmless and stop the chain reaction formation of new free radicals. The use of antioxidant dietary supplements at a maintenance level may provide the ultimate defense against premature aging and a compromised immune system. At therapeutic levels, natural antioxidants may actually play a significant role in reversing many of the effects of aging.* 

NOTE: Item cannot be shipped to Australia.

More Information
More Information


Ingredient Supporting Studies:

1. Stephen Barrett, M.D. "Antioxidants and Related Phytochemicals: Current Scientific Perspective." Quackwatch November 14, 2012. (Accessed 28 Jan 2015.) http://www.quackwatch.org/03HealthPromotion/antioxidants.html

2. "UCL study questions basis for treatment of diseases including cancer and arthritis" UCL News 26 February 2004. (Accessed 29 Jan 2015.) http://www.ucl.ac.uk/news/news-articles/news-releases-archive/oxygen

3. de Rijk MC, Breteler MM, et al. "Dietary antioxidants and Parkinson disease. The Rotterdam Study." Arch Neurol. 1997 Jun;54(6):762-5. http://www.ncbi.nlm.nih.gov/pubmed/9193212

4. "Free Radical Cancer Biology Program." University of Iowa Hospitals & Clinics. (Accessed 29 Jan 2015.) http://www.uihealthcare.org/otherservices.aspx?id=21027

5. Etienne Pigeolet, Philippe Corbisier, et al. "Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals." Mech Ageing Dev. 1990 Feb 15;51(3):283-97. http://www.ncbi.nlm.nih.gov/pubmed/2308398

6. B H Segal, P Veys, H Malech, M J Cowan. "Chronic Granulomatous Disease: Lessons from a Rare Disorder." Biol Blood Marrow Transplant. Jan 2011; 17(1 Suppl): S123--S131. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052948/

7. Elizabeth G. Phimister, Navdeep S. Chandel, David A. Tuveson. "The Promise and Perils of Antioxidants for Cancer Patients." NEJM, 2014; 371 (2):  177. http://www.nejm.org/doi/full/10.1056/NEJMcibr1405701

8. Hughes DA, Wright AJ, Finglas PM, et al. "The effect of beta-carotene supplementation on the immune function of blood monocytes from healthy male nonsmokers." J Lab Clin Med. 1997 Mar;129(3):309-17. http://www.ncbi.nlm.nih.gov/pubmed/9042816

9. Vitamin-Mineral Manufacturing Guide: Nutrient Empowerment, Vol. 1.+ Lakeport, CA: Nutrition Resource, 1986.

10. Min KB, Min JY. "Serum carotenoid levels and risk of lung cancer death in US adults." Cancer Sci. 2014 Jun;105(6):736-43. http://www.ncbi.nlm.nih.gov/pubmed/24673770

11. Pelucchi C, Tramacere I, Bertuccio P, et al. "Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study." Ann Oncol. 2009 Jan;20(1):160-5. http://www.ncbi.nlm.nih.gov/pubmed/18669867

12. Umesawa M, Iso H, Mikami K, et al. "Relationship between vegetable and carotene intake and risk of prostate cancer: the JACC study." Br J Cancer. 2014 Feb 4;110(3):792-6. http://www.ncbi.nlm.nih.gov/pubmed/24169341

13. Pantavos A, Ruiter R, Feskens EF, et al. "Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: The Rotterdam study." Int J Cancer. 2014 Oct 4. http://www.ncbi.nlm.nih.gov/pubmed/25284450

14. Hung RJ, Zhang ZF, Rao JY, et al. "Protective effects of plasma carotenoids on the risk of bladder cancer." J Urol. 2006 Sep;176(3):1192-7. http://www.ncbi.nlm.nih.gov/pubmed/16890724

15. Zhang M, Holman CD, Binns CW. "Intake of specific carotenoids and the risk of epithelial ovarian cancer." Br J Nutr. 2007 Jul;98(1):187-93. http://www.ncbi.nlm.nih.gov/pubmed/17367574

16. Millen AE, Tucker MA, et al. "Diet and melanoma in a case-control study." Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):1042-51. http://www.ncbi.nlm.nih.gov/pubmed/15184262

17. Asha Badaloo, Marvin Reid, Terrence Forrester, et al. "Cysteine supplementation improves the erythrocyte glutathione synthesis rate in children with severe edematous malnutrition1--3." Am J Clin Nutr 2002;76:646--52. http://ajcn.nutrition.org/content/76/3/646.full.pdf+html

18. Giorgia Volpi, Fabrizio Facchinetti, et al. "Cigarette smoke and a,ß-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts." Br J Pharmacol. Jun 2011; 163(3): 649--661. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101625/

19. Carlsten C, MacNutt MJ, et al. "Anti-oxidant N-acetylcysteine diminishes diesel exhaust-induced increased airway responsiveness in person with airway hyper-reactivity." Toxicol Sci. 2014 Jun;139(2):479-87. http://www.ncbi.nlm.nih.gov/pubmed/24814479

20. Blesa S, Cortijo J, Mata M, et al. "Oral N-acetyl cysteine attenuates the rat pulmonary inflammatory response to antigen." Eur Respir J. 2003 Mar;21(3):394-400. http://erj.ersjournals.com/content/21/3/394.long

21. Majano PL, Medina J, Zubia I, et al. "N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human hepatocytes." J Hepatol. 2004 Apr;40(4):632-7. http://www.ncbi.nlm.nih.gov/pubmed/15030979

22. A El Hafiza, L  El Wakeelb, et al. "High dose N-acetyl cysteine improves inflammatory response and outcome in patients with COPD exacerbations." Egyptian Journal of Chest Diseases and Tuberculosis. Volume 62, Issue 1, January 2013, Pages 51--57. http://www.sciencedirect.com/science/article/pii/S0422763813000253

23. Siddiqui A, Ancha H, Tedesco D, et al. "Antioxidant therapy with N-acetyl cysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis." Dig Dis Sci. 2006 Apr;51(4):698-705. http://www.ncbi.nlm.nih.gov/pubmed/16614991

24. Geiler J, Michaelis M, et al. "N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus." Biochem Pharmacol. Feb 1;79(3):413-20. http://www.sciencedirect.com/science/article/pii/S000629520900728X

25. Kim H, Seo JY, Roh KH, et al. "Suppression of NF-kappaB activation and cytokine production by N-acetyl cysteine in pancreatic acinar cells." Free Radic Biol Med. 2000 Oct 1;29(7):674-83. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202196/pdf/10981515.pdf

26. Chen G, Shi J, Hu Z, Hang C. "Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetyl cysteine." Mediators Inflamm. 2008;2008:716458. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375967/

27. Günther M, Noll F, et al. "Harnwegsinfektprophylaxe -- Urinansäuerung mittels L-Methionin bei neurogener Blasenfunktionsstörung." Der Urologe (B). 2002; 218-220. http://link.springer.com/article/10.1007%2Fs00131-002-0207-x#page-1

28. Le NH, Kim CS, Park T, et al. "Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy." Mediators Inflamm. 2014;2014:834294. http://www.ncbi.nlm.nih.gov/pubmed/25614714

29. RT Ferreira,  MAS Coutinho, et al. "Mechanisms Underlying the Antinociceptive, Antiedematogenic, and Anti-Inflammatory Activity of the Main Flavonoid from Kalanchoe pinnata." Evid Based Complement Alternat Med. 2014; 2014: 429256. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279175/

30. Townsend EA, Emala CW Sr. "Quercetin acutely relaxes airway smooth muscle and potentiates ß-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCß and PDE4." Am J Physiol Lung Cell Mol Physiol. 2013 Sep;305(5):L396-403. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763034/

31. Zbikowska HM, Antosik A, et al. "Does quercetin protect human red blood cell membranes against irradiation" Redox Rep. 2014 Mar;19(2):65-71. http://www.ncbi.nlm.nih.gov/pubmed/24257622

32. van der Woude H, Ter Veld MG, et al. "The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor." Mol Nutr Food Res. 2005 Aug;49(8):763-71. http://www.ncbi.nlm.nih.gov/pubmed/15937998

33. Kobylinska A, Janas KM. "Health - promoting effect of quercetin in human diet." Postepy Hig Med Dosw (Online). 2015 Jan 9;69(0):51-62. http://www.ncbi.nlm.nih.gov/pubmed/25589713

34. Ameneh Mashayekh, Dzung L. Pham, et al. "Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study." Neuroradiology. Mar 2011; 53(3): 185--191. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163160/

35. Beth E. Snitz, Ellen S. O'Meara, et al. "Ginkgo biloba for Preventing Cognitive Decline in Older Adults." JAMA. 2009;302(24):2663-2670. http://jama.jamanetwork.com/article.aspx?articleid=185120

36. "Alzheimer's disease: Can Ginkgo products help?" PubMed Health Last Update: July 18, 2013. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0005095/

37. Li M, Yange B, Yu H, Zhang H. "Clinical observation of the therapeutic effect of ginkgo leaf concentrated oral liquor on bronchial asthma." Chinese Journal of Integrative Medicine. 1997;3:264--7. http://link.springer.com/article/10.1007%2FBF02934827#page-1

38. Chu X, Ci X, He J, et al. "A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway." Molecules. 2011 Sep 6;16(9):7634-48. http://www.mdpi.com/1420-3049/16/9/7634

39. Max H Pittler, Edzard Ernst. "Ginkgo Biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials." The American Journal of Medicine. Volume 108, Issue 4, March 2000, Pages 276--281. http://www.sciencedirect.com/science/article/pii/S0002934399004544

40. Moon, S.O., W. Kim, et al. "Resveratrol Suppresses Tumor Necrosis Factor-alpha-Induced Fractalkine Expression in Endothelial Cells." Mol Pharmacol 70 (2006): 112--119. http://molpharm.aspetjournals.org/content/70/1/112.long

41. Khan A, Aljarbou AN, et al. "Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway." Cancer Epidemiol. 2014 Dec;38(6):765-72. http://www.ncbi.nlm.nih.gov/pubmed/25448084

42. Park JB. "Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells." J Nat Prod. 2001 Mar;64(3):381-4. http://www.ncbi.nlm.nih.gov/pubmed/11277764

43. Fiori JL, Shin YK, et al. "Resveratrol Prevents ß--cell Dedifferentiation in Non-Human Primates Given a High Fat/High Sugar Diet." Diabetes. 2013 Oct;62(10):3500-13. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781448/

44. Ponzo V, Soldati L, Bo S. "Resveratrol: a supplementation for men or for mice?" J Transl Med. 2014 Jun 3;12:158. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049475/

45. Baur, J.A., K.J. Pearson, et al. "Resveratrol Improves Health and Survival of Mice on a High-calorie Diet." Nature 444 (November 2006): 337--342. http://www.ncbi.nlm.nih.gov/pubmed/17086191

46. Vesna Milacic,Sanjeev Banerjee,et al. "Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo." Cancer Res. 2008 Sep 15; 68(18): 7283--7292. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556983/

47. Marie-Hélène Teiten, François Gaascht, et al. "Chemopreventive potential of curcumin in prostate cancer." Genes Nutr. Mar 2010; 5(1): 61--74. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820199/

48. Dongwu Liu and Zhiwei Chen. "The Effect of Curcumin on Breast Cancer Cells." J Breast Cancer. Jun 2013; 16(2): 133--137. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706856/

49. Stuart P. Weisberg, Rudolph Leibel, and Drew V. Tortoriello. "Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity." Endocrinology. Jul 2008; 149(7): 3549--3558. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453081/

50. Renu A Kowluru and Mamta Kanwar. "Effects of curcumin on retinal oxidative stress and inflammation in diabetes." Nutr Metab (Lond). 2007; 4: 8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868028/

51. Preetha Anand, Ajaikumar B. Kunnumakkara, et al. "Bioavailability of Curcumin: Problems and Promises." Mol. Pharmaceutics, 2007, 4 (6), 807-818.  http://pubs.acs.org/doi/full/10.1021/mp700113r

52. Chi Chiu Wang, Hui Xu, et al. "Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice." Angiogenesis. 2013 Jan;16(1):59-69. http://www.ncbi.nlm.nih.gov/pubmed/22948799

53. Chang CW, Hsieh YH, Yang WE, et al. "Epigallocatechingallate inhibits migration of human uveal melanoma cells via downregulation of matrix metalloproteinase-2 activity and ERK1/2 pathway." Biomed Res Int. 2014;2014:141582. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145379/

54. Imad Naasani, Fujiko Oh-hashi, et al. "Blocking Telomerase by Dietary Polyphenols Is a Major Mechanism for Limiting the Growth of Human Cancer Cells in Vitro and in Vivo1." Cancer Res February 15, 2003 63; 824. http://cancerres.aacrjournals.org/content/63/4/824.full

55. Hsieh SR, Cheng WC, et al. "Molecular targets for anti-oxidative protection of green tea polyphenols against myocardial ischemic injury." Biomedicine (Taipei). 2014;4:23. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264984/

56. Hakim IA, Chow HH, Harris RB. "Green tea consumption is associated with decreased DNA damage among GSTM1-positive smokers regardless of their hOGG1 genotype." J Nutr. 2008 Aug;138(8):1567S-1571S. http://www.ncbi.nlm.nih.gov/pubmed/18641208

57. Ayokunle O. Ademosun and Ganiyu Oboh. "Comparison of the Inhibition of Monoamine Oxidase and Butyrylcholinesterase Activities by Infusions from Green Tea and Some Citrus Peels." International Journal of Alzheimer's Disease. Volume 2014 (2014), Article ID 586407, 5 pages. http://www.hindawi.com/journals/ijad/2014/586407/

58. Egert S, Tereszczuk J, Wein S, et al. "Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans." Eur J Nutr. 2013 Feb;52(1):281-8. http://www.ncbi.nlm.nih.gov/pubmed/22366739

59. Chung HK, Choi SM, Ahn BO, et al. "Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy." Arzneimittelforschung. 2005;55(10):573-80. http://www.ncbi.nlm.nih.gov/pubmed/16294503

60. Fursova AZh, Gesarevich OG, et al. "[Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senesce-accelerated OXYS rats.]" Adv Gerontol. 2005;16:76-9. http://www.ncbi.nlm.nih.gov/pubmed/16075680

61. Karlsen A, Paur I, Bøhn S.V, et al. "Bilberry juice modulates plasma concentration of NF-?B related inflammatory markers in subjects at increased risk of CVD." Eur J Nutr. 2010 2010 February 2;49:345--55. http://www.ncbi.nlm.nih.gov/pubmed/20119859

62. Takikawa M, Inoue S, Horio F, Tsuda T. "Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice." J Nutr. 2010 Mar;140(3):527-33. http://jn.nutrition.org/content/140/3/527.long

63. Kalanithi Nesaretnam, Puvaneswari Meganathan, et al. "Tocotrienols and breast cancer: the evidence to date." Genes Nutr. Jan 2012; 7(1): 3--9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250526/

64. Serbinova E, Kagan V, Han D, Packer L. "Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol." Free Radic Biol Med. 1991;10(5):263-75. http://www.ncbi.nlm.nih.gov/pubmed/1649783

65. Constantinou C, Papas A, Constantinou AI. "Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs." Int J Cancer. 2008 Aug 15;123(4):739-52. http://www.ncbi.nlm.nih.gov/pubmed/1649783

66. Wada S. "Chemoprevention of tocotrienols: the mechanism of antiproliferative effects." Forum Nutr. 2009;61:204-16. http://www.ncbi.nlm.nih.gov/pubmed/19367124

67. Suzuki YJ, Tsuchiya M, Wassall SR, et al. "Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency." Biochemistry. 1993 Oct 12;32(40):10692-9.. http://www.ncbi.nlm.nih.gov/pubmed/8399214

68. Godeau, R.L., C. Gavignet-Jeannin, et al. "The Effect of Procyanidolic Oligomers on Vascular Permeability: A Study Using Quantitative Morphology." Pathol Biol (Paris) 38:6 (June 1990): 608--616. http://www.ncbi.nlm.nih.gov/pubmed/2165237

69. Belcaro G, Dugall M, et al. "Improvements of venous tone with pycnogenol in chronic venous insufficiency: an ex vivo study on venous segments." Int J Angiol. 2014 Mar;23(1):47-52. http://www.ncbi.nlm.nih.gov/pubmed/24627617

70. Cesarone MR, Belcaro G, Rohdewald P, et al. "Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study." Phytomedicine. 2010 Sep;17(11):835-9. http://www.ncbi.nlm.nih.gov/pubmed/20579863

71. Myburgh KH, Kruger MJ, Smith C. "Accelerated skeletal muscle recovery after in vivo polyphenol administration." J Nutr Biochem. 2012 Sep;23(9):1072-9. http://www.ncbi.nlm.nih.gov/pubmed/22079208

72. Li M, Ma YB, Gao HQ, et al. "A novel approach of proteomics to study the mechanism of action of grape seed proanthocyanidin extracts on diabetic retinopathy in rats." Chin Med J (Engl). 2008 Dec 20;121(24):2544-52. http://www.ncbi.nlm.nih.gov/pubmed/?term=grape+seed+extract+retinopathy

73. Dinicola S, Pasqualato A, et al. "Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion." Eur J Nutr. 2014;53(2):421-31. http://www.ncbi.nlm.nih.gov/pubmed/23754570

74. Kampa M, Theodoropoulou K, et al. "Novel oligomeric proanthocyanidin derivatives interact with membrane androgen sites and induce regression of hormone-independent prostate cancer." J Pharmacol Exp Ther. 2011 Apr;337(1):24-32. http://www.ncbi.nlm.nih.gov/pubmed/21205921

75. Kumar S, Kumar D, Raina K, et al. "Functional modification of adipocytes by grape seed extract impairs their pro-tumorigenic signaling on colon cancer stem cells and the daughter cancer cells." Oncotarget. 2014 Oct 30;5(20):10151-69. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259412/

76. Chen H, Teng L, Li JN, et al. "Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA." J Med Chem. 1998 Jul 30;41(16):3001-7. http://www.ncbi.nlm.nih.gov/pubmed/9685239

77. Zhao J, Zhao Y, Chen W, et al. "The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8." Anticancer Drugs. 2008 Aug;19(7):713-9. http://www.ncbi.nlm.nih.gov/pubmed/18594213

78. Chen, H., L. Teng, J.N. Li, et al. "Antiviral Activities of Methylated Nordihydroguaiaretic Acids." J Med Chem 41:16 (July 1998): 3001--3007. http://www.ncbi.nlm.nih.gov/pubmed/9685239 

79. Gao P1, Zhai F, Guan L, Zheng J. "Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21." Oncol Lett. 2011 Jan;2(1):123-128. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412500/

80. Lü JM, Nurko J, et al. "Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update." Med Sci Monit. 2010 May;16(5):RA93-100. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927326/

81. Goodman Y, Steiner MR, et al. "Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation." Brain Res. 1994;654:171--6. http://www.ncbi.nlm.nih.gov/pubmed/7982093

82. Eads D, Hansen R, Oyegunwa A, et al. "Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines." J Inflamm (Lond) 2009;6:2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631502/

83. Hwu JR, Hsu CI, et al. "Glycosylated nordihydroguaiaretic acids as anti-cancer agents." Bioorg Med Chem Lett. 2011 Jan 1;21(1):380-2. http://www.ncbi.nlm.nih.gov/pubmed/21123067

84. Hsu MH, Wu SC, et al. "Hepatocellular carcinoma targeting agents: conjugates of nitroimidazoles with trimethyl nordihydroguaiaretic Acid." ChemMedChem. 2014 May;9(5):1030-7. http://www.ncbi.nlm.nih.gov/pubmed/24648164

85. Zhang Y, Xu S, Lin J, et al. "mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo." Breast Cancer Res Treat. 2012 Nov;136(2):379-88. http://www.ncbi.nlm.nih.gov/pubmed/23053656

86. Ryan CJ, Zavodovskaya M, et al. "Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells." Prostate. 2008 Aug 1;68(11):1232-40. http://www.ncbi.nlm.nih.gov/pubmed/18491370

87. RAJINDAR S. SOHAL. "Mitochondria generate superoxide anion radicals and hydrogen peroxide." The FASEB Journal. 1270 Vol. 11 December 1997. 1269-70. http://www.fasebj.org/content/11/14/1269.full.pdf

88. L. Benov. "How superoxide radical damages the cell." 2001, Protoplasma Volume 217, Issue 1-3, pp 33-36. http://link.springer.com/article/10.1007/BF01289410

89. Busse E, Zimmer G, Schopohl B, Kornhuber B. "Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo." Arzneimittelforschung. 1992 Jun;42(6):829-31. http://www.ncbi.nlm.nih.gov/pubmed/1418040

90. Giorgia Mellia, Michela Taianaa, et al. "Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy." Experimental Neurology. Volume 214, Issue 2, December 2008, Pages 276--284. http://www.sciencedirect.com/science/article/pii/S0014488608003312

91. Ashu Johri and M. Flint Beal. "Mitochondrial Dysfunction in Neurodegenerative Diseases." J Pharmacol Exp Ther. 2012 Sep; 342(3): 619--630. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422529/

92. Lin MT1, Beal MF. "Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases." Nature. 2006 Oct 19;443(7113):787-95. http://www.ncbi.nlm.nih.gov/pubmed/17051205

93. Hardas SS, Sultana R, Clark AM, et al. "Oxidative modification of lipoic acid by HNE in Alzheimer disease brain." Redox Biol. 2013 Jan 30;1:80-5. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757677/

94. Lei Zhanga, Gou qaing Xingb, et al. "a-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway." Neurosci Lett. 2001 Oct 26;312(3):125-8. http://www.ncbi.nlm.nih.gov/pubmed/11602326

95. Pershadsingh HA. "Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome." Expert Opin Investig Drugs. 2007 Mar;16(3):291-302. http://www.ncbi.nlm.nih.gov/pubmed/17302524

96. Zhao L1, Hu FX. "a-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction." Eur Rev Med Pharmacol Sci. 2014 Dec;18(23):3715-9. http://www.europeanreview.org/article/8177

97. Richer S, Stiles W, et al. "Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)." Optometry. 2004 Apr;75(4):216-30. http://www.ncbi.nlm.nih.gov/pubmed/15117055

98. Slattery ML, Benson J, Curtin K, Ma KN, Schaeffer D, Potter JD. "Carotenoids and colon cancer." Am J Clin Nutr 2000 Feb;71(2):575-82. http://ajcn.nutrition.org/content/71/2/575.long

99. SanGiovanni JP, Chew EY, Clemons TE, et al. "The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22." Arch Ophthalmol. 2007 Sep;125(9):1225-32. http://www.ncbi.nlm.nih.gov/pubmed/17846363

100. Hung RJ

101. Jian L, Lee AH, Binns CW. "Tea and lycopene protect against prostate cancer." Asia Pac J Clin Nutr. 2007;16 Suppl 1:453-7. http://apjcn.nhri.org.tw/server/APJCN/16%20Suppl%201//453.pdf

102. Badmaev, V, Majeed, M. et al. "Piperine, An Alkaloid Derived from Black Pepper, Increases Serum Response of Beta-Carotene During 14 Days of Oral Beta-Carotene Supplementation." Nutrition Research, 19(3) 381-388, 1999. http://www.sciencedirect.com/science/article/pii/S027153179900007X

103. Shoba G, et al. "Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers." Planta Med; 64(4):353-6. 1998. http://www.ncbi.nlm.nih.gov/pubmed/9619120

104. Prasad PD, Wang H, Huang W, et al. "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter." Arch Biochem Biophys. 1999;366(1):95-106. http://www.ncbi.nlm.nih.gov/pubmed/10334869

105. Balamurugan K, Vaziri ND, Said HM. "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects." Am J Physiol Renal Physiol. 2005;288(4):F823-831. http://ajprenal.physiology.org/content/288/4/F823

106. Zempleni J, Trusty TA, Mock DM. "Lipoic acid reduces the activities of biotin-dependent carboxylases in rat liver." J Nutr. 1997;127(9):1776-1781. http://jn.nutrition.org/content/127/9/1776.long

107. Liu R, Wang T, Zhang B, et al. "Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration." Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):252-8. http://www.ncbi.nlm.nih.gov/pubmed/25515572

108. Ming-Chao Bi, Richard Rosen, et al. "Zeaxanthin Induces Apoptosis in Human Uveal Melanoma Cells through Bcl-2 Family Proteins and Intrinsic Apoptosis Pathway." Evid Based Complement Alternat Med. 2013; 2013: 205082. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810440/

109. Schriner SE, Linford NJ, Martin GM, et al. "Extension of murine life span by overexpression of catalase targeted to mitochondria." Science. 2005 Jun 24;308(5730):1909-11. http://www.ncbi.nlm.nih.gov/pubmed/15879174

110. Sinitsyna O, Krysanova Z, et al. "Age-associated changes in oxidative damage and the activity of antioxidant enzymes in rats with inherited overgeneration of free radicals." J Cell Mol Med. 2006 Jan-Mar;10(1):206-15. http://www.ncbi.nlm.nih.gov/pubmed/16563232

111. Sarang Dilip Pophalya, Poonama, et al. "Selenium enrichment of lactic acid bacteria and bifidobacteria: A functional food perspective." Trends in Food Science & Technology. Volume 39, Issue 2, October 2014, Pages 135--145. http://www.sciencedirect.com/science/article/pii/S0924224414001587

112. Nagy G, Benko I, Kiraly G, et al. "Cellular and nephrotoxicity of selenium species." J Trace Elem Med Biol. 2015 Jan 6. pii: S0946-672X(14)00262-4. http://www.ncbi.nlm.nih.gov/pubmed/25604949

113. http://www.centrum.ca/learn/vitamins-minerals/selenium

114. "Selenium." NIH July 02, 2013. (Accessed 28 Jan 2015.) http://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/#en36

115. Ayrton, A.D., et al. "Antimutagenicity of Ellagic Acid Towards the Food Mutagen IQ: Investigation into Possible Mechanisms of Action." Food Chem Toxicol 30:4 (1992): 289-95. http://www.ncbi.nlm.nih.gov/pubmed/1628864

116. Constantinou, A., et al. "The Dietary Anticancer Agent Ellagic Acid is a Potent Inhibitor of DNA Topoisomerases in Vitro." Nutr Cancer 23:2 (1995):121--130. http://www.ncbi.nlm.nih.gov/pubmed/7644381

117. Aviram, M., L. Dornfeld, M. Rosenblat, et al. "Pomegranate Juice Consumption Reduces Oxidative Stress, Atherogenic Modifications to LDL, and Platelet Aggregation: Studies in Humans and in Atherosclerotic Apolipoprotein E-Deficient Mice." Am J Clin Nutr 71:5 (2000): 1062--1076. http://www.ncbi.nlm.nih.gov/pubmed/10799367

118. Serafini MR1, Santos RC, et al. "Morinda citrifolia Linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration." J Med Food. 2011 Oct;14(10):1159-66. http://www.ncbi.nlm.nih.gov/pubmed/21548805

119. Katherine C. Wood, Miriam M. Cortese-Krott, Jason C. Kovacic, et al. "Circulating Blood eNOS Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis." Arterioscler Thromb Vasc Biol. Aug 2013; 33(8). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864011/

120. Isla S Mackenzie, Daniel Rutherford,Thomas M MacDonald. "Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis." Arthritis Res Ther. 2008; 10(Suppl 2): S3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582806/

121. Gan, L., S.H. Zhang, Q. Liu, et al. "A Polysaccharide-Protein Complex from Lycium barbarum Upregulates Cytokine Expression in Human Peripheral Blood Mononuclear Cells." Eur J Pharmacol 471:3 (June 2003): 217--222. http://www.ncbi.nlm.nih.gov/pubmed/12826241

122. Luo, Q., J. Yan, S. Zhang. "Isolation and Purification of Lycium barbarum Polysaccharides and Its Anti-fatigue Effect." Wei Sheng Yan Jiu 29:2 (March 2000): 115--117. http://www.ncbi.nlm.nih.gov/pubmed/12725093

123. Zhang, X. "Experimental Research on the Role of Lycium barbarum Polysaccharide in Anti-peroxidation." Zhongguo Zhong Yao Za Zhi 18:2 (February 1993): 110--112, 128. http://www.ncbi.nlm.nih.gov/pubmed/8323695

124. Fabiola Gutierrez-Orozco and Mark L. Failla1. "Biological Activities and Bioavailability of Mangosteen Xanthones: A Critical Review of the Current Evidence." Nutrients. Aug 2013; 5(8): 3163--3183. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775248/

125. Gutierrez-Orozco


Take 3 capsules of Ultimate Antioxidant™ per day with food. Best if taken 1 capsule with each meal.

For special situations you may take up to 12 capsules of Ultimate Antioxidant™ per day.

Supplement Facts

Serving Size: 3 Capsules
Servings per Container: 30
Amount per Serving: 2157 mg
Container Size: 90 Capsules
Strength: 750 mg
Click ingredient for more information
Amount Per Serving % Daily Value
Vitamin A (as alpha/beta carotene) 5,250 IU 105%
Biotin 1.8 mg 600%
Selenium (as Methylselenocysteine) 55 mcg 79%
NAC 225 mg N/A*
L-Methionine 225 mg N/A*
Quercetin 180 mg N/A*
Ginkgo (24/6) 180 mg N/A*
Resveratrol (50%) 150 mg N/A*
Green Tea (95%) 120 mg N/A*
Bilberry (25%) 120 mg N/A*
Curcumin C3 Complex ® 120 mg N/A*
Tocotrienols (7.5%) 100 mg N/A*
Chaparral (4:1) 100 mg N/A*
OPCs (95-97%) 100 mg N/A*
SOD 75 mg N/A*
R. Lipoic Acid 50 mg N/A*
Lutein 10 mg N/A*
Lycopene 6 mg N/A*
Bioperine 4,500 mcg N/A*
Zeaxanthin 500 mcg N/A*
Catalase 300 mcg N/A*
Other ingredients: Vegetable Gelatin
All ingredients are either domestically sourced or selectively imported
* Daily Value Not Established

No materials used to produce this product are derived from or contain any Genetically Modified Organisms (GMOs)

Cannot Ship to Australia

Curcumin C3 Complex® is a registered trademark of Sabinsa Corp.


Vitamin A (as alpha/beta carotene)

Carotenoids are phytonutrients that protect plants from damage caused by UV radiation and other environmental factors. In humans, they have been shown to inhibit the proliferation of various types of damaging cells such as those affecting the lungs, stomach, cervix, breast, bladder, and mouth. They also have been proven to protect against atherosclerosis, cataracts, macular degeneration and other major degenerative disorders. The key carotenoids are: beta carotene, alpha carotene, lycopene, and zeaxanthin.

Probably the best known of the carotenoids, beta carotene is converted by the body into vitamin A as needed to strengthen the immune system and promote healthy cell growth. In addition, beta carotene is a potent antioxidant, offering particular benefits to the immune system and the lungs. (Note: synthetic beta carotene, made from acetylene gas is to be avoided. As a side note, synthetic beta carotene was used in the studies that produced negative results when beta carotene was tested.)

But also, it is important to understand that beta carotene is not the most important of the carotenoids. It's just the only one that is a recommended daily requirement. Once again, the FDA and the USDA are several decades behind the times.

For example, recent studies have shown that alpha carotene is one of the most powerful carotenoids and has a strong inhibitory effect on the proliferation of various types of damaging cells such as those affecting the lungs, stomach, cervix, breast, bladder and mouth. It works by allowing normal cells to send growth-regulating signals to premalignant cells.

Bottom line. You want a carotenoid complex, not pure synthetic beta carotene.


Biotin is a water soluble vitamin which can be depleted by stress. It is essential in the conversion of carbohydrates to energy and plays a major role in fat and protein metabolism for building healthy tissue. Biotin works synergistically with insulin to lower blood sugar levels in diabetics especially at higher doses of 10-20 mg. When taking high doses of alpha lipoic acid, it is important to also take biotin because alpha lipoic acid can compete with biotin and interfere with its activity in the body.

Selenium (as Methylselenocysteine)

Food sources provide selenium in either an inorganic form (selenite or selenate) or in an organic form where it displaces sulfur in methionine or cysteine. The organic forms are far more absorbable and display no toxicity.

Selenium is a component of glutathione peroxidases which are primarily responsible for reducing peroxide free radicals that include lipid peroxide formation in cell membranes. Reduction of peroxides breaks the auto-oxidative chain reaction that damages cell membranes. Selenium is synergistic with glutathione and catalase in helping to protect the integrity of cell membranes. It helps protect the liver.


One of the keys to a healthy immune system is maintaining high levels of glutathione in the body. Unfortunately, supplementing with glutathione doesn't really help. Fortunately, there are alternatives. Supplementation with N-acetyl-cysteine (NAC) has been proven to substantially raise the body's glutathione levels. In addition, NAC supplementation is mandatory for all smokers and big-city dwellers as it protects against toxic aldehydes that enter the body through cigarette smoke and pollution.


An essential sulfur amino acid, methionine is a powerful antioxidant and liver detoxifier -- where it assists in the normal detoxification processes. As an natural antioxidant, it provides powerful protection in the colon. Finally, methionine is involved in the synthesis of choline, adrenaline, lecithin, and B12, and it works as a powerful SAMe precursor.


Quercetin is one of the class of natural antioxidants known as bioflavonoids. A prime role of quercetin is to protect the integrity of cell walls from free radical damage. In addition, quercetin inhibits the release of histamines into the bloodstream, thereby helping to control food and pollen allergies.

Ginkgo (24/6)

Known as the brain antioxidant, Ginkgo Biloba has been shown to increase brain function, which makes it useful in helping to improve concentration and memory. This makes it a specific for Alzheimer's, where it has the added benefit of helping to significantly reduce depression. In addition, Ginkgo Biloba oxygenates the blood, increases circulation, and strengthens blood vessels. Ginkgo Biloba's anti-inflammatory, lung-relaxant properties have proven helpful with asthma, where it eases coughing and reduces tissue inflammation.

Resveratrol (50%)

When Ultimate Antioxidant first started using resveratrol in 2004, almost no one in the alternative health community had heard of it. Users of this remarkable formula back then got a head start of several years on the rest of world. Originally, Jon Barron specified 30 mg at 20%. In the new formulation, it's now 150 mg at 50%. That represents a 1250% increase in this possibly life-extending ingredient!!

Green Tea (95%)

Green tea antioxidants are of the same family as grape seed and pine bark extracts. They are polyphenols, chief of which are the flavonoids called proanthocyanidins. In green tea, the main proanthocyanidins are the catechins, and the most powerful of the catechins is Epigallocatechin Gallate (EGCG), found in the highest concentration in green tea.

Green tea as a health supplement works to help stop tumors from developing the blood vessels they need to survive. It has been shown to inhibit metastasis. And it is the first known natural telomerase inhibitor.

And the benefits of green tea don't stop there. It has also been shown to be helpful in regulating blood sugar, reducing triglycerides, and in reversing the ravages of heart disorders. (Incidentally, the Japanese, who drink large amounts of green tea, have some of the lowest rates of cardiovascular disorders in the world.)

Finally, green tea has great benefits for the brain as well, serving as a helpful MAO inhibitor, protecting against brain-cell death from glucose oxidase, over-production of nitric oxide, and lowering the amount of free iron reaching the brain (a bad thing). The net result is that there are strong indications that green tea extract may play a major role in protecting against both Parkinson's and Alzheimer's.

Bilberry (25%)

The anthocyanosides found in bilberry are known for their ability to help nourish and repair the tiny capillaries within the eye. In addition, the bilberry bioflavonoids are beneficial to the connective tissue that lines blood vessels and binds ligaments throughout the body. Traditionally, bilberry's leaves and berries have been used to help with scurvy, urinary tract issues or challenges, kidney problems, and diarrhea. British pilots during World War II would eat bilberry jam before night raids in order to improve their vision.

Curcumin C3 Complex ®

Curcumin is one of the most powerful and most studied antioxidants in existence. Research has focused on its potential as an anti-inflammatory and anti-malignancy agent. This formula was recently upgraded from a standard, 95% curcumin extract to a patented version that balances out the three main chemical compounds - Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin - collectively known as Curcuminoids. The benefits are profound.

Tocotrienols (7.5%)

Derived from rice bran or palm oil, tocotrienols are a unique vitamin E fraction that is 40 times more powerful than standard vitamin E. Tocotrienols are rich in the gamma tocotrienol fraction of vitamin E. Specifically, tocotrienols can:

  • Reduce cholesterol
  • Reverse arteriosclerosis
  • Protect against heart injury
  • Inhibit blood platelet aggregation
  • Work as a sugar antioxidant
  • Inhibit the appearance of aging
  • Lower blood pressure

Chaparral (4:1)

Native Americans have used Chaparral leaf for centuries. Exactly how it works is open to debate, but some of its main actions are:

•Chaparral leaf is one of the most powerful anti-oxidants in nature. The primary biochemical responsible for this is NDGA (nordihydroguaiaretic acid) - so effective, it is often used as a food preservative.

•Chaparral leaf cleanses the lymph system.

•It is a powerful blood purifier.

•It cleanses the liver.

•It cleanses the urinary tract.

•Studies show that chaparral may also inhibit cell proliferation as well as DNA synthesis.

So how could such a beneficial herb be on everyone's blacklist?

According to the FDA, Chaparral: sold has been linked to serious liver damage. FDA has recorded two deaths and 10 cases of hepatitis or other liver abnormalities in users.

The reality, though, is that the evidence for chaparral liver toxicity is anecdotal. It is not the result of any double blind studies or of any clinical trials. For example, one of the cases the FDA likes to single out can be found in the Journal of the American Medical Association (273 (6):489). The details of the case concern a 60-year-old woman who developed jaundice and liver failure while taking one to two capsules of chaparral each day with a pinch of garlic in a tea made from nettle and chickweed. The authors of the JAMA article concluded it was the chaparral that caused the liver problems. What is fascinating is that the patient in question was also consuming atenolol, aspirin, was on a nitro patch, and occasional acetaminophen, as well as diltiazem hydrochloride - all drugs with profound hepatoxic potential. Amazingly, none of these other substances was even considered as a possible cause of the liver problems by the authors...or the FDA. What a surprise!

Nevertheless (and despite the fact that extensive studies on chaparral in the 1970s and 1980s were unable to find any hepatotoxic properties), in December of 1992, FDA Commissioner David Kessler announced, "The public should not purchase or consume chaparral."

After these allegations of liver toxicity by the FDA, manufacturers voluntarily restricted sales of chaparral for several years until the reports were investigated. Following a lengthy review, a panel of medical experts concluded "no clinical data was found... to indicate chaparral is inherently a hepatic toxin." In late 1994, this report was submitted to the FDA. The American Herbal Products Association (AHPA) now recommends the following Companies that offer products for sale for internal use that contain chaparral (Larrea tridentata) [should] provide labeling that contains the following informational language:

Rare reports of serious liver disease have been associated with ingestion of chaparral. Seek advice from a health care practitioner before use and, in so doing, inform them if you have had, or may have had, liver disease, frequently use alcoholic beverages, or are using any medications. Discontinue use and see a doctor if vomiting, fever, fatigue, abdominal pain, loss of appetite, or jaundice (e.g., dark urine, pale stools, yellow discoloration of the eyes) should occur.

So is this remarkable herb now sold freely in the marketplace and used to benefit ailing people all over the world? Hardly!

Search for "chaparral toxicity" on the web and you will see numerous articles still announcing the dangers of the herb (all citing the same cases from the early 90's.) Or try and buy chaparral in Canada or much of Europe. Right! The problem is that once an herb is labeled dangerous (even if disproved at a later date), the stigma remains - and is brought up over and over and over again...acquiring truth through repetition, if not fact.

Fortunately, despite the bad press, chaparral, or larrea, is at least available (for the time being) in the United States.

OPCs (95-97%)

Similar to green tea, the active ingredients in grape seed extract are the oligomeric proanthocyanidins (but in a different combination and ratio). The importance of the proanthocyanidins in grape seed extract is that they are water soluble and highly bio-available.

Above all else, grape seed extract is known as a defender of the circulatory system. It improves peripheral circulation, revives declining capillary activity by up to 140%, and increases vascular response by some 82%. It repairs varicose veins and aids in the prevention of bruising.

In addition, grape seed extract is synergistic with vitamin C, vastly increasing vitamin C activity and strengthening collagen activity -- including in the connective tissue of the arterial wall and the skin.

Oligomeric proanthocyanidins (OPCs) clearly possess remarkable antioxidant properties. Their effects on reducing free radical damage and oxidative stress suggest that they may be particularly helpful in reducing the risk of cardiovascular issues and a number of the chronic issues associated with aging. Although the majority of the studies conducted on OPCs have been done in cell culture (test tube) and animals, the results are extremely promising.


Superoxide dismutase (SOD) works along with glutathione to neutralize reactive oxygen molecules in the body. SOD specifically targets the superoxide radical, which, as we discussed earlier, attacks cell mitochondria. When mitochondria are destroyed, the cell loses its ability to convert food to energy. It dies. SOD also works in the cytoplasm of the cell to help keep the hydroxyl radical from attacking enzymes, proteins, and the unsaturated fats in cell membranes.

R. Lipoic Acid

Sometimes called the "Mother" antioxidant, alpha lipoic acid (ALA) plays a major role in helping recycle vitamins E and C so that they can be used over and over again by your body. In its own right, alpha lipoic acid is one of the main boosters of glutathione levels in body cells, and is one of the key co-factors involved in generating energy in the cells mitochondria. In the "new" Ultimate Antioxidant, Jon switched to all natural R. Lipoic Acid (RLA), which is over twice as potent as ALA. Thus, 50 mg of RLA is notably more potent than 100 mg of ALA, as previously used.


Lutein’s antioxidant effect is significantly enhanced by the presence of zeaxanthin, and bilberry. When combined with vitamin C, these three natural antioxidants have been shown to significantly decrease the risk of cataracts.

Lutein and another carotenoid called zeaxanthin are the most dominant pigments in the macular region of the retina. The antioxidant properties of lutein and zeaxanthin help maintain the integrity of the blood vessels that supply the macular region of the retina. Lutein and zeaxanthin provide protection from photo-oxidation, the result of light striking the fatty acids in the retina. It seems that lutein is particularly active against the blue part of the spectrum, which can be the most damaging to our eyes.

One study using lutein supplements resulted in a 15% increase in macular pigment levels after 72 days. In another study, people who consumed the equivalent of 6 mg of lutein per day were 40% less likely to experience macular problems. Another study using sets of identical twins demonstrated that macular lutein concentrations were related to dietary lutein. After consumption, lutein is found in significant quantities in blood serum, suggesting high bioavailability.


Derived primarily from tomatoes (cooked, not raw).


Bioperine, a black pepper extract, serves the same purpose as cayenne serves in liquid tinctures. It drives the other ingredients into the blood and significantly improves their efficacy. In human studies, for example, the bioavailability of curcumin was increased twentyfold when used with bioperine. Bioperine improves the absorption of many vitamins and biochemicals in the intestine, promotes their retention in cells, and helps them not be metabolized in the liver. Effectively, it increases the efficacy of virtually all of the ingredients in this dietary supplement.


Lutein and zeaxanthin are both part of a group of carotenoids known as xanthophylls, which are extremely beneficial to the eyes.

Of the 40 to 50 carotenoids typically consumed in the human diet, lutein and zeaxanthin, are deposited at an up to 5 fold higher content in the macular region of the retina as compared to the peripheral retina. Zeaxanthin is preferentially accumulated in the foveal region, whereas lutein is abundant in the perifoveal region. These pigments are collectively referred to as the macular pigment.

Although the role of the macular pigment remains uncertain, several functions have been hypothesized and these include limitation of the damaging photo-oxidative effects of blue light through its absorption, reduction of the effects of light scatter and chromatic aberration on visual performance, and protection against the adverse effects of photochemical reactions because of the antioxidant properties of the carotenoids.


Glutathione perioxidase, superoxide dismutase, and catalase are the primary three enzymes produced in the body as an antioxidant defense. Catalase is specific for protection against tumors. A little catalase can go a long way: one catalase enzyme molecule can catalyze the breakdown of five million molecules of peroxide radicals into water and oxygen in just one minute.

Vegetable Gelatin

Write Your Own Review
Only registered users can write reviews. Please Sign in or create an account
  Is there a conflict between taking resveratrol and quercetin at the same time?
  How does Ultimate Antioxidant compare to live juice that is loaded with natural antioxidants?
  What is the ORAC value (Oxygen Radical Absorbance Capacity) of Ultimate Antioxidant?
  Could Ultimate Antioxidant be used in place of a multivitamin?
  Do you use grape seed extract in any of your products?
  Can taking high doses of selenium cause negative side effects?
  I read an article about NAC concerns. Ultimate Antioxidant contains N-acetyl-cysteine (NAC). Your thoughts?
  Why is the selenium so low in your Ultimate Antioxidant?
Customers who bought this product also bought: