Women's Formula Additional Information

Reports:

Ingredient Supporting Studies:

  1. Cumming, D.C., S.R. Wall. "Non--Sex Hormone-Binding Globulin-bound Testosterone as a Marker for Hyperandrogenism." J Clin Endocrinol Metab 61 (1985):873--876. http://www.ncbi.nlm.nih.gov/pubmed/4044776
  2. Panzer, C., S. Wise, G. Fantini, et al. "Impact of Oral Contraceptives on Sex Hormone--Binding Globulin and Androgen Levels: A Retrospective Study in Women with Sexual Dysfunction." J Sex Med 3 (2006): 104--113. http://www.ncbi.nlm.nih.gov/pubmed/16409223
  3. Wiegratz I, Kutschera E, Lee JH, et al. "Effect of four different oral contraceptives on various sex hormones and serum-binding globulins." Contraception. 2003 Jan;67(1):25-32. http://www.ncbi.nlm.nih.gov/pubmed/12521654
  4. Toke J, Czirják G, Bezzegh A, et al. "Effects and significance of estradiol in men." Orv Hetil. 2014 Jun 8;155(23):891-6.http://www.ncbi.nlm.nih.gov/pubmed/24880967
  5. Harman SM, Metter EJ, Tobin JD, et al. "Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging." J Clin Endocrinol Metab. 2001 Feb;86(2):724-31. http://www.ncbi.nlm.nih.gov/pubmed/11158037
  6. Davison SL, Bell R, et al. "Androgen levels in adult females: changes with age, menopause, and oophorectomy." J Clin Endocrinol Metab. 2005 Jul;90(7):3847-53. http://www.ncbi.nlm.nih.gov/pubmed/15827095
  7. Jiang H, Chen Z. "Studies on sex hormone-binding globulin in the prostate." Zhonghua Nan Ke Xue. 2004 Jun;10(6):443-4, 448. http://www.ncbi.nlm.nih.gov/pubmed/15267211
  8. Bent S, Kane C, Shinohara K, et. al. "Saw Palmetto for Benign Prostatic Hyperplasia." NEJM. 2006; 354:557-566. http://www.nejm.org/doi/full/10.1056/NEJMoa053085#t=articleTop
  9. "List of references supporting the assessment of Serenoa repens (W. Bartram) Small, fructus." European Medicines Agency. 24 Nov 2014. (Accessed 20 Jun 2015.) http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_List_of_references_supporting_the_assessment_report/2014/12/WC500179594.pdf
  10. Letteria Minutoli, Domenica Altavilla, et al. "Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene." J Biomed Sci. 2014; 21(1): 19. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995880/
  11. Fru Angwafor, III and Mark L Anderson. "An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males." J Int Soc Sports Nutr. 2008; 5: 12. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525623/
  12. Wadsworth TL, Worstell TR, et al. (May 2007). "Effects of dietary saw palmetto on the prostate of transgenic adenocarcinoma of the mouse prostate model (TRAMP)." Prostate. 2007 May 1;67(6):661-73. http://www.ncbi.nlm.nih.gov/pubmed/17342743
  13. Scaglione F, Lucini V, Pannacci M, et al. "Comparison of the potency of different brands of Serenoa repens extract on 5alpha-reductase types I and II in prostatic co-cultured epithelial and fibroblast cells." Pharmacology. 2008;82(4):270-5. http://www.ncbi.nlm.nih.gov/pubmed/18849646
  14. Abe M, Ito Y, Oyunzul L, et al. "Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extract." Biol Pharm Bull. 2009 Apr;32(4):646-50. https://www.jstage.jst.go.jp/article/bpb/32/4/32_4_646/_article
  15. Habib FK, Ross M, Ho CK, et al. "Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression." Int J Cancer. 2005 Mar 20;114(2):190-4. http://www.ncbi.nlm.nih.gov/pubmed/15543614
  16. Di Silverio F, Monti S, Sciarra A et al. "Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia." Prostate. 1998 Oct 1;37(2):77-83. http://www.ncbi.nlm.nih.gov/pubmed/9759701
  17. Plosker GL, Brogden RN. "Serenoa repens (Permixon). A review of its pharmacology and therapeutic efficacy in benign prostatic hyperplasia." Drugs Aging. 1996 Nov;9(5):379-95. http://www.ncbi.nlm.nih.gov/pubmed/8922564
  18. Prager N, Bickett K, French N, Marcovici G. "A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia." J Altern Complement Med. 2002 Apr;8(2):143-52. http://www.ncbi.nlm.nih.gov/pubmed/12006122
  19. Gansser D, Spiteller G. "Plant constituents interfering with human sex hormone-binding globulin. Evaluation of a test method and its application to Urtica dioica root extracts." Z Naturforsch C. 1995 Jan-Feb;50(1-2):98-104. http://www.ncbi.nlm.nih.gov/pubmed/7702715
  20. Schmidt K. "Effect of radix urticae extract and its several secondary extracts on blood SHBG in benign prostate hyperplasia." Fortschr Med. 1983 Apr 21;101(15):713-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472916/
  21. Hryb DJ, Khan MS, Romas NA, Rosner W. "The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes." Planta Med. 1995 Feb;61(1):31-2. http://www.ncbi.nlm.nih.gov/pubmed/7700987
  22. WHO Monograph of Selected Herbals volume 2." WHO http://apps.who.int/medicinedocs/pdf/s4927e/s4927e.pdf
  23. Safarinejad MR. "Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study." J Herb Pharmacother. 2005;5(4):1-11. http://www.ncbi.nlm.nih.gov/pubmed/16635963
  24. Nahata A, Dixit VK. "Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats." Andrologia. 2012 May;44 Suppl 1:396-409. http://www.ncbi.nlm.nih.gov/pubmed/21806658
  25. Leonard S Marks. "5a-Reductase: History and Clinical Importance."  Rev Urol. 2004; 6(Suppl 9): S11--S21. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472916/
  26. Rogerson S, Riches CJ, Jennings C, et al. "The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players." J Strength Cond Res. 2007 May;21(2):348-53. http://www.ncbi.nlm.nih.gov/pubmed/17530942
  27. Qureshi A, Naughton DP, Petroczi A. "A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect." J Diet Suppl. 2014 Mar;11(1):64-79. http://www.ncbi.nlm.nih.gov/pubmed/24559105
  28. Jungmo Do, Seemin Choi, et al. "Effects and Mechanism of Action of a Tribulus terrestris Extract on Penile Erection." Korean J Urol. 2013 Mar; 54(3): 183--188. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604572/
  29. Carlos RB Gama,Ricardo Lasmar, et al. "Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction." Clin Med Insights Womens Health. 2014; 7: 45--50. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275110/
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  32. Waynberg, J. Male Sexual Asthenia--Interest in a Traditional Plant-Derived Medication. Ethnopharmacology, March 1995. (Accessed 22 Jun 2015.) http://www.rain-tree.com/clinic/clinic_a.htm#.VYhi3tH_Gbg
  33. Waynberg J, Brewer S. "Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women."  Adv Ther. 2000 Sep-Oct;17(5):255-62. http://www.ncbi.nlm.nih.gov/pubmed/11186145
  34. Estrada-Reyes R, Carro-Juárez M, Martínez-Mota L. "Pro-sexual effects of Turnera diffusa Wild (Turneraceae) in male rats involves the nitric oxide pathway." J Ethnopharmacol. 2013 Mar 7;146(1):164-72. http://www.ncbi.nlm.nih.gov/pubmed/23298455
  35. Hnatyszyn O, Moscatelli V, Garcia J, et al. "Argentinian plant extracts with relaxant effect on the smooth muscle of the corpus cavernosum of guinea pig." Phytomedicine. 2003;10(8):669-674. http://www.ncbi.nlm.nih.gov/pubmed/14692728
  36. Estrada-Reyes, R., et al. "Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males." J Ethnopharmacol. 2009 Jun 25;123(3):423-9. http://www.ncbi.nlm.nih.gov/pubmed/19501274
  37. Arletti R, Benelli A, et al. "Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual-behavior of male rats." Psychopharmacology (Berl). 1999 Mar;143(1):15-9. http://www.ncbi.nlm.nih.gov/pubmed/10227074
  38. Yakoot M1, Salem A, Omar AM. "Effectiveness of a herbal formula in women with menopausal syndrome." Forsch Komplementmed. 2011;18(5):264-8. http://www.ncbi.nlm.nih.gov/pubmed/22105039
  39. Pecio L, Wawrzyniak-Szolkowska A, et al. "Rapid analysis of avenacosides in grain and husks of oats by UPLC-TQ-MS." Food Chem. 2013 Dec 1;141(3):2300-4. http://www.ncbi.nlm.nih.gov/pubmed/23870961
  40. Berry NM, Robinson MJ, Bryan J, et al. "Acute effects of an Avena sativa herb extract on responses to the Stroop Color-Word test." J Altern Complement Med. 2011 Jul;17(7):635-7. http://www.ncbi.nlm.nih.gov/pubmed/21711204
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  42. Nair R, Sellaturay S, Sriprasad S. "The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE)." Indian J Urol. 2012;28(1):15-20. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339779/
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  44. Chan SW. "Panax ginseng, Rhodiola rosea and Schisandra chinensis." Int J Food Sci Nutr. 2012;1:75-81. http://www.ncbi.nlm.nih.gov/pubmed/22039930
  45. Kim TH, Jeon SH, Hahn EJ, et al. "Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction." Asian J Androl. 2009;11(3):356-361. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735289/
  46. Jang DJ, Lee MS, Shin BC, et al. "Red ginseng for treating erectile dysfunction: a systematic review." Br J Clin Pharmacol. 2008;66(4):444-450. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561113/
  47. Wang X, Chu S, Qian T, et al. "Ginsenoside Rg1 improves male copulatory behavior via nitric oxide/cyclic guanosine monophosphate pathway." J Sex Med. 2010;7(2 Pt 1):743-750. http://www.ncbi.nlm.nih.gov/pubmed/19751391
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