Women's Formula Additional Information


Ingredient Supporting Studies:

  1. Cumming, D.C., S.R. Wall. "Non--Sex Hormone-Binding Globulin-bound Testosterone as a Marker for Hyperandrogenism." J Clin Endocrinol Metab 61 (1985):873--876. http://www.ncbi.nlm.nih.gov/pubmed/4044776
  2. Panzer, C., S. Wise, G. Fantini, et al. "Impact of Oral Contraceptives on Sex Hormone--Binding Globulin and Androgen Levels: A Retrospective Study in Women with Sexual Dysfunction." J Sex Med 3 (2006): 104--113. http://www.ncbi.nlm.nih.gov/pubmed/16409223
  3. Wiegratz I, Kutschera E, Lee JH, et al. "Effect of four different oral contraceptives on various sex hormones and serum-binding globulins." Contraception. 2003 Jan;67(1):25-32. http://www.ncbi.nlm.nih.gov/pubmed/12521654
  4. Toke J, Czirják G, Bezzegh A, et al. "Effects and significance of estradiol in men." Orv Hetil. 2014 Jun 8;155(23):891-6.http://www.ncbi.nlm.nih.gov/pubmed/24880967
  5. Harman SM, Metter EJ, Tobin JD, et al. "Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging." J Clin Endocrinol Metab. 2001 Feb;86(2):724-31. http://www.ncbi.nlm.nih.gov/pubmed/11158037
  6. Davison SL, Bell R, et al. "Androgen levels in adult females: changes with age, menopause, and oophorectomy." J Clin Endocrinol Metab. 2005 Jul;90(7):3847-53. http://www.ncbi.nlm.nih.gov/pubmed/15827095
  7. Jiang H, Chen Z. "Studies on sex hormone-binding globulin in the prostate." Zhonghua Nan Ke Xue. 2004 Jun;10(6):443-4, 448. http://www.ncbi.nlm.nih.gov/pubmed/15267211
  8. Bent S, Kane C, Shinohara K, et. al. "Saw Palmetto for Benign Prostatic Hyperplasia." NEJM. 2006; 354:557-566. http://www.nejm.org/doi/full/10.1056/NEJMoa053085#t=articleTop
  9. "List of references supporting the assessment of Serenoa repens (W. Bartram) Small, fructus." European Medicines Agency. 24 Nov 2014. (Accessed 20 Jun 2015.) http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_List_of_references_supporting_the_assessment_report/2014/12/WC500179594.pdf
  10. Letteria Minutoli, Domenica Altavilla, et al. "Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene." J Biomed Sci. 2014; 21(1): 19. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995880/
  11. Fru Angwafor, III and Mark L Anderson. "An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males." J Int Soc Sports Nutr. 2008; 5: 12. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525623/
  12. Wadsworth TL, Worstell TR, et al. (May 2007). "Effects of dietary saw palmetto on the prostate of transgenic adenocarcinoma of the mouse prostate model (TRAMP)." Prostate. 2007 May 1;67(6):661-73. http://www.ncbi.nlm.nih.gov/pubmed/17342743
  13. Scaglione F, Lucini V, Pannacci M, et al. "Comparison of the potency of different brands of Serenoa repens extract on 5alpha-reductase types I and II in prostatic co-cultured epithelial and fibroblast cells." Pharmacology. 2008;82(4):270-5. http://www.ncbi.nlm.nih.gov/pubmed/18849646
  14. Abe M, Ito Y, Oyunzul L, et al. "Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extract." Biol Pharm Bull. 2009 Apr;32(4):646-50. https://www.jstage.jst.go.jp/article/bpb/32/4/32_4_646/_article
  15. Habib FK, Ross M, Ho CK, et al. "Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression." Int J Cancer. 2005 Mar 20;114(2):190-4. http://www.ncbi.nlm.nih.gov/pubmed/15543614
  16. Di Silverio F, Monti S, Sciarra A et al. "Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia." Prostate. 1998 Oct 1;37(2):77-83. http://www.ncbi.nlm.nih.gov/pubmed/9759701
  17. Plosker GL, Brogden RN. "Serenoa repens (Permixon). A review of its pharmacology and therapeutic efficacy in benign prostatic hyperplasia." Drugs Aging. 1996 Nov;9(5):379-95. http://www.ncbi.nlm.nih.gov/pubmed/8922564
  18. Prager N, Bickett K, French N, Marcovici G. "A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia." J Altern Complement Med. 2002 Apr;8(2):143-52. http://www.ncbi.nlm.nih.gov/pubmed/12006122
  19. Gansser D, Spiteller G. "Plant constituents interfering with human sex hormone-binding globulin. Evaluation of a test method and its application to Urtica dioica root extracts." Z Naturforsch C. 1995 Jan-Feb;50(1-2):98-104. http://www.ncbi.nlm.nih.gov/pubmed/7702715
  20. Schmidt K. "Effect of radix urticae extract and its several secondary extracts on blood SHBG in benign prostate hyperplasia." Fortschr Med. 1983 Apr 21;101(15):713-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472916/
  21. Hryb DJ, Khan MS, Romas NA, Rosner W. "The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes." Planta Med. 1995 Feb;61(1):31-2. http://www.ncbi.nlm.nih.gov/pubmed/7700987
  22. WHO Monograph of Selected Herbals volume 2." WHO http://apps.who.int/medicinedocs/pdf/s4927e/s4927e.pdf
  23. Safarinejad MR. "Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study." J Herb Pharmacother. 2005;5(4):1-11. http://www.ncbi.nlm.nih.gov/pubmed/16635963
  24. Nahata A, Dixit VK. "Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats." Andrologia. 2012 May;44 Suppl 1:396-409. http://www.ncbi.nlm.nih.gov/pubmed/21806658
  25. Leonard S Marks. "5a-Reductase: History and Clinical Importance."  Rev Urol. 2004; 6(Suppl 9): S11--S21. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472916/
  26. Rogerson S, Riches CJ, Jennings C, et al. "The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players." J Strength Cond Res. 2007 May;21(2):348-53. http://www.ncbi.nlm.nih.gov/pubmed/17530942
  27. Qureshi A, Naughton DP, Petroczi A. "A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect." J Diet Suppl. 2014 Mar;11(1):64-79. http://www.ncbi.nlm.nih.gov/pubmed/24559105
  28. Jungmo Do, Seemin Choi, et al. "Effects and Mechanism of Action of a Tribulus terrestris Extract on Penile Erection." Korean J Urol. 2013 Mar; 54(3): 183--188. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604572/
  29. Carlos RB Gama,Ricardo Lasmar, et al. "Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction." Clin Med Insights Womens Health. 2014; 7: 45--50. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275110/
  30. Rowland DL, Tai W. "A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions." J Sex Marital Ther. 2003;29(3):185-205. http://www.ncbi.nlm.nih.gov/pubmed/12851124
  31. Waynberg, J. "Aphrodisiacs: Contributions to the Clinical Validation of the Traditional Use of Ptychopetalum guyanna." Presented at the First International Congress on Ethnopharmacology, Strasbourg, France, June 5--9, 1990
  32. Waynberg, J. Male Sexual Asthenia--Interest in a Traditional Plant-Derived Medication. Ethnopharmacology, March 1995. (Accessed 22 Jun 2015.) http://www.rain-tree.com/clinic/clinic_a.htm#.VYhi3tH_Gbg
  33. Waynberg J, Brewer S. "Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women."  Adv Ther. 2000 Sep-Oct;17(5):255-62. http://www.ncbi.nlm.nih.gov/pubmed/11186145
  34. Estrada-Reyes R, Carro-Juárez M, Martínez-Mota L. "Pro-sexual effects of Turnera diffusa Wild (Turneraceae) in male rats involves the nitric oxide pathway." J Ethnopharmacol. 2013 Mar 7;146(1):164-72. http://www.ncbi.nlm.nih.gov/pubmed/23298455
  35. Hnatyszyn O, Moscatelli V, Garcia J, et al. "Argentinian plant extracts with relaxant effect on the smooth muscle of the corpus cavernosum of guinea pig." Phytomedicine. 2003;10(8):669-674. http://www.ncbi.nlm.nih.gov/pubmed/14692728
  36. Estrada-Reyes, R., et al. "Turnera diffusa Wild (Turneraceae) recovers sexual behavior in sexually exhausted males." J Ethnopharmacol. 2009 Jun 25;123(3):423-9. http://www.ncbi.nlm.nih.gov/pubmed/19501274
  37. Arletti R, Benelli A, et al. "Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual-behavior of male rats." Psychopharmacology (Berl). 1999 Mar;143(1):15-9. http://www.ncbi.nlm.nih.gov/pubmed/10227074
  38. Yakoot M1, Salem A, Omar AM. "Effectiveness of a herbal formula in women with menopausal syndrome." Forsch Komplementmed. 2011;18(5):264-8. http://www.ncbi.nlm.nih.gov/pubmed/22105039
  39. Pecio L, Wawrzyniak-Szolkowska A, et al. "Rapid analysis of avenacosides in grain and husks of oats by UPLC-TQ-MS." Food Chem. 2013 Dec 1;141(3):2300-4. http://www.ncbi.nlm.nih.gov/pubmed/23870961
  40. Berry NM, Robinson MJ, Bryan J, et al. "Acute effects of an Avena sativa herb extract on responses to the Stroop Color-Word test." J Altern Complement Med. 2011 Jul;17(7):635-7. http://www.ncbi.nlm.nih.gov/pubmed/21711204
  41. Mark A Moyad and Kwangsung Park. "What do most erectile dysfunction guidelines have in common? No evidence-based discussion or recommendation of heart-healthy lifestyle changes and/or Panax ginseng." Asian J Androl. 2012 Nov; 14(6): 830--841. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720104/
  42. Nair R, Sellaturay S, Sriprasad S. "The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE)." Indian J Urol. 2012;28(1):15-20. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339779/
  43. de Andrade E, de Mesquita AA, et al. "Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction." Asian J Androl. 2007;9(2):241-244. http://www.asiaandro.com/news/upload/20130912-aja200728a.pdf
  44. Chan SW. "Panax ginseng, Rhodiola rosea and Schisandra chinensis." Int J Food Sci Nutr. 2012;1:75-81. http://www.ncbi.nlm.nih.gov/pubmed/22039930
  45. Kim TH, Jeon SH, Hahn EJ, et al. "Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction." Asian J Androl. 2009;11(3):356-361. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735289/
  46. Jang DJ, Lee MS, Shin BC, et al. "Red ginseng for treating erectile dysfunction: a systematic review." Br J Clin Pharmacol. 2008;66(4):444-450. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561113/
  47. Wang X, Chu S, Qian T, et al. "Ginsenoside Rg1 improves male copulatory behavior via nitric oxide/cyclic guanosine monophosphate pathway." J Sex Med. 2010;7(2 Pt 1):743-750. http://www.ncbi.nlm.nih.gov/pubmed/19751391
  48. Kim TH
  49. de Andrade E
  50. Su Kang Kim, Joo-Ho Chung,et al. "Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia." Int Neurourol J. 2014 Dec; 18(4): 179--186. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280437/
  51. Campos MM, Fernandes ES, Ferreira J, Santos AR, Calixto JB. Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology (Berl). 2005 Oct;182(1):45-53. http://www.ncbi.nlm.nih.gov/pubmed/15991001
  52. Agung Heru Karsono, et al. "Molecular effects of bioactive fraction of Curcuma mangga (DLBS4847) as a downregulator of 5a-reductase activity pathways in prostatic epithelial cells." Cancer Manag Res. 2014; 6: 267--278. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057330/
  53. Suphrom N, Pumthong G, Khorana N, et al. "Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb." Fitoterapia. 2012 Jul;83(5):864-71. http://www.ncbi.nlm.nih.gov/pubmed/22465508
  54. Guo H, Xu Y, Fu Q. "Curcumin inhibits growth of prostate carcinoma via miR-208-mediated CDKN1A activation." Tumour Biol. 2015 Jun 2. http://www.ncbi.nlm.nih.gov/pubmed/26032092
  55. Agung Heru Karsono
  56. Sato K, Fujita S, Iemitsu M. "Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats." J Steroid Biochem Mol Biol. 2014 Sep;143:152-9. http://www.ncbi.nlm.nih.gov/pubmed/24607838
  57. Park MK, Kwon HY, Ahn WS, et al. "Estrogen activities and the cellular effects of natural progesterone from wild yam extract in mcf-7 human breast cancer cells." Am J Chin Med. 2009;37(1):159-67. http://www.ncbi.nlm.nih.gov/pubmed/19222119
  58. Badalzadeh R, Yousefi B, Majidinia M, Ebrahimi H. "Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel." J Physiol Sci. 2014 Nov;64(6):393-400. http://www.ncbi.nlm.nih.gov/pubmed/25150984
  59. Wojcikowski K1, Wohlmuth H, Johnson DW, Gobe G. "Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways." Food Chem Toxicol. 2008 Sep;46(9):3122-31. http://www.ncbi.nlm.nih.gov/pubmed/18662738
  60. Alexander Panossian, Georg Wikman, et al. "Adaptogens Stimulate Neuropeptide Y and Hsp72 Expression and Release in Neuroglia Cells." Front Neurosci. 2012; 6: 6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269752/
  61. Farnsworth NR, Kinghorn AD, et al. "Siberian ginseng (Eleutherococcus senticosus): Current status as an adaptogen." In: WAGNER, H.; HIKINO, H. and FARNSWORTH, N.R. eds. Economic and Medicinal Plant Research. London, Academic Press, 1985, p. 155-215
  62. Huang LZ, Huang BK, Ye Q, Qin LP. "Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus." J Ethnopharmacol. 2011 Jan 7;133(1):213-9. https://www.ncbi.nlm.nih.gov/pubmed/20920564
  63. Bohn B, Nebe CT, Birr C. "Flow cytometric studies with  Eleutherococcus senticosus extract as an immunomodulating agent." Arzneim-Forsch Drug Res 1987;37:1193--6. http://www.ncbi.nlm.nih.gov/pubmed/2963645
  64. Al-Dujaili EA, Kenyon CJ, Nicol MR, Mason JI. "Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity." Mol Cell Endocrinol. 2011 Apr 10;336(1-2):102-9. http://www.ncbi.nlm.nih.gov/pubmed/21184804
  65. Brown D. "Licorice root - potential early intervention for chronic fatigue syndrome." Quart Rev Nat Medicine Summer:95-97, 1996.
  66. Ashfaq UA, Masoud MS, Nawaz Z, Riazuddin S. "Glycyrrhizin as antiviral agent against Hepatitis C Virus." J Transl Med. 2011 Jul 18;9:112. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169469/
  67. Jing Chen, Chao-Mei Xiong, Shan-Shan Song, et al. "Fraction of Macroporous Resin from Smilax china L. Inhibits Testosterone Propionate--Induced Prostatic Hyperplasia in Castrated Rats." J Med Food. 2012 Jul; 15(7): 646--650. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382266/
  68. Brian J. Doyle, Jonna Frasor, et al. "Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms." Menopause. 2009 Jul--Aug; 16(4): 748--755. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756988/
  69. Challinor VL, Parsons PG, Chap S, et al. "Steroidal saponins from the roots of Smilax sp.: structure and bioactivity." Steroids. 2012 Apr;77(5):504-11. http://www.ncbi.nlm.nih.gov/pubmed/22285850
  70. Lakshmi BV, Sudhakar M. "Attenuation of acute and chronic restraint stress-induced perturbations in experimental animals by Zingiber officinale Roscoe." Food Chem Toxicol. 2010 Feb;48(2):530-5. http://www.ncbi.nlm.nih.gov/pubmed/19909780
  71. ashefi F, Khajehei M, Alavinia M, et al. "Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial." Phytother Res. 2015 Jan;29(1):114-9. http://www.ncbi.nlm.nih.gov/pubmed/25298352
  72. Raina AP, Khatri R. "Quantitative Determination of L-DOPA in Seeds of Mucuna Pruriens Germplasm by High Performance Thin Layer Chromatography." Indian J Pharm Sci. 2011 Jul;73(4):459-62. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374567/
  73. Mahajan GK, Mahajan AY, Mahajan RT. "Efficacy of aphrodisiac plants towards improvement in semen quality and motility in infertile males." J Complement Integr Med. 2012 Feb 17;9:Article 6. http://www.ncbi.nlm.nih.gov/pubmed/22499723
  74. Lucia Raffaella Lampariello, Alessio Cortelazzo, et al. "The Magic Velvet Bean of Mucuna pruriens." J Tradit Complement Med. 2012 Oct-Dec; 2(4): 331--339. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942911/
  75. https://youtu.be/OHug0AIhVoQ