Looking for the ultimate joint formula to provide the nutrients your body needs for cartilage regeneration? Then you have to try Baseline Nutritionals'® Triple Jointed™.
Optimum Cartilage Regeneration & Joint Health Supplement:
- Joint Formula to nutritionally support the growth of cartilage.
- May help slow down and reverse the immune system's attack on joints and cartilage.
- Nutritionally supports the reduction of joint inflammation.
- Lubricates joints and muscles.
- Contains Avocado Soy Unsaponifiables, Boswellin® PS**, & Undenatured Chicken Collagen.
- Alternative approach to glucosamine and chondroitin.
This dietary supplement offers a five-pronged approach to systemically support your body's joints and provide nutritional support to help moderate the inflammation response.
- CMO (cetyl myristoleate) to help lubricate the joints.
- Avocado soy unsaponifiables to increase aggrecan levels and cartilage regeneration, thereby helping to repair and rebuild weight bearing joints. Boswellin® PS** to provide nutritional support to help moderate the inflammation response.
- UC-II chicken collagen to nutritionally support the body's immune system so that it is less inclined to attack joint cartilage.
- Ginger's nutritional support to help reduce pain and inflammation.*
Ingredient Supporting Studies:
Christelle Sanchez, Michelle A Deberg, Nathalie Piccardi, et al. "Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes." J Rheumatol August 2003 30(8):1825-1834. http://www.jrheum.org/content/30/8/1825.abstract
2. Appelboom T, Schuermans J, et al. "Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study." Scand J Rheumatol. 2001;30(4):242-7. http://www.ncbi.nlm.nih.gov/pubmed/11578021
3. Maheu E, Cadet C, Marty M, Moyse D, et al. "Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study." Ann Rheum Dis. 2014 Feb;73(2):376-84. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913295/
4. Andriamanalijaona R, Benateau H, et al. "Effect of interleukin-1beta on transforming growth factor-beta and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture: modulation by avocado and soybean unsaponifiables." J Periodontol. 2006 Jul;77(7):1156-66. http://www.ncbi.nlm.nih.gov/pubmed/16805677
5. Kut-Lasserre C, Miller CC, Ejeil AL, et al. "Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (TIMP- 1 and TIMP-2) secretion by human fibroblasts in culture." J Periodontol. 2001 Dec;72(12):1685-94. http://www.ncbi.nlm.nih.gov/pubmed/11811504
6. Kut C, Assoumou A, Dridi M, et al. "Morphometric analysis of human gingival elastic fibres degradation by human leukocyte elastase protective effect of avocado and soybean unsaponifiables (ASU)." Pathol Biol (Paris). 1998 Sep;46(7):571-6. http://www.ncbi.nlm.nih.gov/pubmed/9842576
7. Bagchi D, Misner B, Bagchi M, et al. "Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration." Int J Clin Pharmacol Res. 2002;22(3-4):101-10. http://www.ncbi.nlm.nih.gov/pubmed/12837047
8. David C. Crowley, Francis C. Lau, et al. "Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial." Int J Med Sci. 2009; 6(6): 312--321. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764342/
10. Trentham, RA Dynesius-Trentham, et al., "Effects of Oral Administration of Type II collagen on Rheumatoid Arthritis." Science, 261:1727-1730, 1993. http://www.sciencemag.org/content/261/5129/1727.abstract
11. "Celebrex, Vioxx and Bextra News." Consumer Affairs. (Accessed 11 May 2015.) http://www.consumeraffairs.com/celebrex-vioxx-and-bextra-news
12. Srivastava KC, Mustafa T. "Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders." Med Hypotheses. 1992 Dec;39(4):342-8. http://www.ncbi.nlm.nih.gov/pubmed/1494322
13. Altman RD, Marcussen KC. "Effects of a ginger extract on knee pain in patients with osteoarthritis." Arthritis Rheum. 2001 Nov;44(11):2531-8. http://www.ncbi.nlm.nih.gov/pubmed/11710709
15. Wigler I, Grotto I, Caspi D, Yaron M. "The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis." Osteoarthritis and Cartilage November 2003 Volume 11, Issue 11, Pages 783--789. http://www.oarsijournal.com/article/S1063-4584(03)00169-9/abstract
16. El-Akabawy G, El-Kholy W. "Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats." Ann Anat. 2014 May;196(2-3):119-28. http://www.ncbi.nlm.nih.gov/pubmed/24680376
17. Yang M, Liu C, Jiang J, Zuo G, Lin X, et al. "Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats." BMC Complement Altern Med. 2014 May 27;14(1):174. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047007/
18. Moon M, Kim HG, Choi JG, Oh H, et al. "6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia." Biochem Biophys Res Commun. 2014 Jun 20;449(1):8-13. http://www.ncbi.nlm.nih.gov/pubmed/24796668
19. Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. "Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats." Rejuvenation Res. 2013 Apr;16(2):124-33. http://www.ncbi.nlm.nih.gov/pubmed/23374025
20. Diehl HW, May EL. "Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats." J Pharm Sci. 1994 Mar;83(3):296-9. http://www.ncbi.nlm.nih.gov/pubmed/8207671
21. H. Siemandi, et al. "The Effect of cis-9-Cetyl Myristoleate (CMO) and Adjunctive Therapy on Arthritis and Auto-Immune Disease: A Randomized Trial. The Townsend Letter for Doctors and Patients. Aug 1997;169/170: 58-63
22. Hesslink R, Jr, Armstrong D, III, et al. "Cetylated fatty acids improve knee function in patients with osteoarthritis." J Rheumatol. 2002;29:1708--1712. http://www.ncbi.nlm.nih.gov/pubmed/12180734
23. Hunter KW, Jr. Gault RA, Stehouwer JS, Tam-Chang SW. "Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis." Pharmacol Res. 2003 Jan;47(1):43-7. http://www.ncbi.nlm.nih.gov/pubmed?term=12526860%20
24. Umar S, Umar K, Sarwar AH, et al. "Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis." Phytomedicine. 2014 May 15;21(6):847-56. http://www.ncbi.nlm.nih.gov/pubmed/24667331
25. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M. "Frankincense ( ru xiang; boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases." J Tradit Complement Med. 2013 Oct;3(4):221-6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924999/
26. Togni S, Maramaldi G, et al. "A cosmeceutical formulation based on boswellic acids for the treatment of erythematous eczema and psoriasis." Clin Cosmet Investig Dermatol. 2014 Nov 11;7:321-7. http://www.ncbi.nlm.nih.gov/pubmed/25419153
27. Gupta PK, Samarakoon SM, et al. "Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis)." Ayu. 2011 Oct;32(4):478-82. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361921/
28. Ammon HP. "Modulation of the immune system by boswellia serrata extracts and boswellic acids." Phytomedicine. 2010 Sep;17(11):862-7. Epub 2010 Aug 8. http://www.ncbi.nlm.nih.gov/pubmed/20696559
29. Reichling J, Schmökel H, Fitzi J, et al. "Dietary support with Boswellia resin in canine inflammatory joint and spinal disease." Schweiz Arch Tierheilkd. 2004 Feb;146(2):71-9. http://www.ncbi.nlm.nih.gov/pubmed/14994484
30. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. "Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial." Phytomedicine. 2003 Jan;10(1):3-7. http://www.ncbi.nlm.nih.gov/pubmed/12622457
31. Gupta I, Gupta V, Parihar A, et al. "Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study." Eur J Med Res. 1998 Nov 17;3(11):511-4. http://www.ncbi.nlm.nih.gov/pubmed/9810030
32. Gerhardt H, Seifert F, Buvari P, et al. "[Therapy of active Crohn disease with Boswellia serrata extract H 15]." Z Gastroenterol. 2001 Jan;39(1):11-7. http://www.ncbi.nlm.nih.gov/pubmed/11215357
33. Roy S, Khanna S, Krishnaraju AV, et al. "Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia." Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):653-60. http://www.ncbi.nlm.nih.gov/pubmed/16677108
34. Ammon HP. "Boswellic acids in chronic inflammatory diseases." Planta Med. 2006 Oct;72(12):1100-16. http://www.ncbi.nlm.nih.gov/pubmed/17024588
Take 3 capsules of Triple Jointed™ before bed on an empty stomach.
This dietary supplement can also be taken with food and at other times of the day but will be most effective if taken as instructed above. If you experience any discomfort, reduce to 1 capsule. Increase slowly.
|Serving Size:||3 Capsules|
|Servings per Container:||30|
|Amount per Serving:||1133 mg|
|Container Size:||90 Capsules|
|Click ingredient for more information|
|Amount Per Serving||% Daily Value|
|Cetyl Myristoleate||500 mg||N/A|
|Avocado Soy Unsaponifiables||333 mg||N/A|
|Ginger Extract 5%||125 mg||N/A|
|Boswellin® PS**||100 mg||N/A|
|UC-II® Standardized Cartilage||40 mg ***||N/A|
|Ionic Trace Minerals||35 mg||N/A|
|Other ingredients: Cellulose, Vegetable Stearate, Silicon Dioxide|
All ingredients are either domestically sourced or selectively imported
* Daily Value Not Established
** Boswellia serrata extract standardized to 35% organic acids
*** Yielding 10% Total Collagen
Boswellin® PS is a registered mark of Sabinsa Corporation. Patent Pending.
Patented UC-ll® brand undenatured type ll collagen. (US Patents 7,846,487, 7,083,820) Trademark of InterHealth N.I.
No materials used to produce this product are derived from or contain any Genetically Modified Organisms (GMOs)
Cetyl myristoleate (CMO) is the common name for cis-9-cetyl myristoleate. (a relative of the Omega-9 fatty acid found in olive oil.) It is a completely natural medium chain fatty acid found in certain animals, including cows, whales, beavers, and mice -- but not in people. CMO was discovered in 1972 by Harry W. Diehl, Ph.D., a researcher at the National Institutes of Health. At the time, Dr. Diehl was responsible for testing anti-inflammatory drugs on lab animals. In order for him to test the drugs, he first had to artificially induce arthritis in the animals by injecting a heat-killed bacterium called Freund's adjuvant health supplement. Dr. Diehl discovered that Swiss albino mice did not get arthritis after injection of Freund's adjuvant health supplement. Eventually, he was able to determine that cetyl myristoleate was the factor present naturally in mice that was responsible for this protection. When CMO was injected into various strains of rats, it offered the same protection against arthritis. There have been three notable studies on humans.
The first double blind study was conducted in 1997 under the auspices of the Joint European Hospital Studies Program. Of the 106 people who received cetyl myristoleate, 63% showed improvement VS just 15% for the 226 people in the placebo group.
In 2001, a study of 1814 arthritis patients found that over 87% of the subjects in the study had greater than 50% recovery and over 65% of those showed from 75% - 100% recovery following a sixteen day regimen. All types of arthritis were positively affected by CMO. Only those subjects with liver damage or digestive problems or those taking immune suppressing medications were not helped.
In 2002, a double blind study of 64 people with chronic knee pain, published in the Journal or Rheumatology, concluded that CMO provided a significant functional improvement in range of motion VS placebo. In fact, the study concluded that CMO "may be an alternative to the use of nonsteroidal anti-inflammatory drugs for the treatment of osteoarthritis."
The CMO is sourced from bovine tallow.
Avocado Soy Unsaponifiables
Several years ago, researchers from the University Hospital in Liege, Belgium reported in the August 2003 issue of The Journal of Rheumatology that an extract made from the oils found tightly bound to avocado and soybean fibers could significantly boost production of aggrecan, thereby helping slow down and even repair some of the damage caused by osteoarthritis -- in as little as nine days.
It should be noted that although eating avocado and soybean oil separately does indeed enhance aggrecan production (somewhat); it is only this special ASU extract (made up of one-third avocado and two-thirds soybean unsaponifiables) that restores aggrecan synthesis blocked by the inflammation-causing compound interleukin-1-beta. In addition, ASUs also reduced levels of several other inflammatory factors such as MMP-3 production. In other words, ASU health supplement is not the same as avocado and soy oil. It is specially extracted from the fiber of avocados and soy. The problem is that before extraction, the ASUs are so tightly bound to the fiber, that they are mostly unusable by the human body.
Aggrecan plays a crucial role in the functioning of articular cartilage (the cartilage found in joints), primarily working to maintain high levels of hydration in the cartilage – thereby keeping the cartilage healthy and functional.
Note: all ASU comes in a 30% concentration by weight. 50% of the blend is soy protein isolate -- which may present a problem for those allergic to soy protein. However, that works out to only 165 mg of soy protein in an average daily dose of Triple Jointed™.
Ginger Extract 5%
Ginger has a long history of use in herbal medicine.
- Ginger root helps control temporary nausea, which makes it useful in morning sickness during pregnancy, as well as in intestinal activating and detoxing formulas, and in liver cleansing programs.
- Ginger root is also a strong COX 2 inhibitor.
- In the far east and India, ginger root is renowned for its aphrodisiac properties.
Boswellia serrata, the Indian version of frankincense, has been a staple of Ayurvedic medicine from time immemorial for its ability to manage inflammatory disorders. Positive effects of boswellia in some chronic inflammatory diseases including rheumatoid arthritis, bronchial asthma, osteoarthritis, ulcerative colitis and Crohn's disease have been reported.1 Until recently, research on boswellia has focused almost exclusive on the boswellic acids, particularly AKBA (acetyl-11-keto-beta-boswellic acid) as the most active component in boswellia, and supplements such as 5-LOXIN® have looked to maximize that component. However, more current research has indicated that some of the water soluble polysaccharides in boswellia are also essential components in that they initiate and support the anti-inflammatory activity, whereas the lipid-soluble boswellic acids help to provide a sustained action. In fact, a particular boswellin polysaccharide extract known as Polysal has demonstrated a dose dependent anti-inflammatory potential, similar to the boswellic acids.
For the following reasons, Boswellin® PS now stands out as the boswellin ingredient of choice.
- It's 100% natural.
- It has enhanced AKBA content VS regular boswellin extracts - although less than 5-LOXIN®.
- But in addition to the active boswellic acids, Boswellin® PS contains Polysal, the exclusive water soluble polysaccharide components which contribute to an immediate anti-inflammatory action - perfectly complementing the more sustained action of AKBA. Polysal primarily consists of galactose, arabinose, D-glucuronic acid, and 4-o-methyl-glucuronoarabino-galactan.
1 Ammon HP. "Modulation of the immune system by boswellia serrata extracts and boswellic acids." Phytomedicine. 2010 Sep;17(11):862-7. Epub 2010 Aug 8. http://www.ncbi.nlm.nih.gov/pubmed/20696559
UC-II® Standardized Cartilage
UC-II is extracted from chicken sternum cartilage using a patented, low-temperature process that ensures the undenatured biological activity of the type II collagen even when exposed to digestive juices for 90 minutes or more. Undenatured collagen administered orally works with the immune system to promote healthy joints by a process called oral tolerization. This process helps the body differentiate between foreign invaders, such as bacteria, and elements that are good for the body, such as nutrients and cartilage. In the case of UC-II, small amounts (typically around 10 milligrams) taken orally have been shown to correct a faulty immune response specifically targeted at the type II collagen present in bone joint cartilage – in effect, modulating the body's immune response so it works correctly once again.
Most type II chicken collagen sold in dietary supplements is denatured, or hydrolyzed, which is another way of saying that the chemicals and high-heat used to process and refine it have changed its molecular configuration. This does not make it useless. Hydrolyzed type II chicken collagen still has great value as a source of some of the components of aggrecan including type II collagen itself, hyaluronic acid, chondroitin and glucosamine. However, one significant thing does change in the process of denaturing; when denatured, type II chicken collagen loses its immunomodulating ability. Type II collagen must be in its native (undenatured) form, such as UC-II to be effective in this capacity.
Ionic Trace Minerals
Ionic minerals are added to many formulas to increase the bio-electric activity level of the ingredients in the formula and sustain their activity for a significantly longer period of time.
Ionic merely means that the minerals are broken down to their absolutely smallest form.
Basic vitamins and minerals are fine, but in general, human supplements are not recommended for pets. Although there are no known problems in using Triple Jointed with pets, it has not been tested on animals and is not recommened at this time. Understand, animals are not people and can quite differently to foods and supplements. For example, chocolate can be toxic for dogs.