pHi-Zymes® 450 Capsules

Current Batch Expiration Date: 4/30/21

Looking to boost your cardiovascular health? Then you have to try Baseline Nutritionals'® patented pHi-Zymes®. This is the world's most powerful, systemic proteolytic enzyme formula that includes Protease, Nattokinase, and Seaprose enzymes.

pHi-Zymes® Support Cardiovascular Health, Endurance, & Performance:

  • World's most powerful systemic proteolytic enzyme formula to help facilitate injury recovery.
  • Helps your body clean out and repair the cardiovascular system for health or athletic performance.
  • Reduces Circulating Immune Complexes that can lead to allergies and systemic inflammation.
  • Optimizes the quality of blood.
  • Helps with factors that can cause autoimmune disorders.
  • Watch Video -  Systemic Proteolytic Enzymes--What works, What Doesn't and Why


Do not take: if nursing or pregnant, if you have history of an ulcer, or if taking blood thinners. Do not take days before having elective surgery.

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If you take a healthy dose of a wide ranging proteolytic (protein digesting) enzyme formula between meals, the enzymes can make their way into the blood stream with a broad array of potential health benefits. Proteolytic enzymes support the body's ability to systemically facilitate injury recovery in all soft tissue, clean out and repair the cardiovascular system, minimize the risk of blood clots, reduce scar tissue, digest fibroid cysts, and digest Circulating Immune Complexes, which helps reduce the symptoms of autoimmune disorders and allergies. For athletes, proteolytic enzymes can also improve performance and reduce recovery time. Note: this formula is so powerful, so unique, and so remarkable that it is patented. pHi-Zymes® are an absolute revolution in systemic proteolytic enzymes.*

NOTE: Item cannot be shipped to Australia. phiz sticker

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Ingredient Supporting Studies:

1. Hedstrom, L. (Dec 2002). "Serine protease mechanism and specificity." Chem Rev 102 (12): 4501--24.

2. Chapman HA, Riese RJ, Shi GP (1997). "Emerging roles for cysteine proteases in human biology." Annu. Rev. Physiol. 59: 63--88.

3. Arazi A1, Neumann AU. "Modeling immune complex-mediated autoimmune inflammation." J Theor Biol. 2010 Dec 7;267(3):426-36.

4. P O Cano, L M Jerry, J P Sladowski, and C K Osterland. "Circulating immune complexes in systemic lupus erythematosus." Clin Exp Immunol. Aug 1977; 29(2): 197--204.

5. Stauder G, Ransberger K, Streichhan P, Van Schaik W, Pollinger W. "The use of hydrolytic enzymes as adjuvant therapy in AIDS/ARC/LAS patients." Biomed Pharmacother. 1988;42(1):31-4.

6. Cecil Adams. "Is it aerodynamically impossible for bumblebees to fly?" The Straight Dope. May 4, 1990. (Accessed 24 Jun 2014.)

7. Brad Rachman, "Unique Features and Application of Non-Animal Derived Enzymes." Clinical Nutrition Insights. 510 8/97 Vol. 5, No. 10. (Accessed 24 Jun 2014.)

8. Laura P. Hale. "Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice." International Immunopharmacology. Volume 4, Issue 2, February 2004, Pages 255--264.

9. KOLAC C., STREICHHAN P., LEHR C.-M. "Oral bioavailability of proteolytic enzymes." European journal of pharmaceutics and biopharmaceutics. 1996, vol. 42, no4, pp. 222-232 (68 ref.)



12. Stauder G. "Pharmacological effects of oral enzyme combinations." Cas Lek Cesk. 1995 Oct 4;134(19):620-4.

13. Nouza K. "Systemic enzyme therapy in diseases of the vascular system." Bratisl Lek Listy. 1995 Oct;96(10):566-9.

14. Beuth J. "Proteolytic enzyme therapy in evidence-based complementary oncology: fact or fiction?" Integr Cancer Ther. 2008 Dec;7(4):311-6. doi: 10.1177/1534735408327251.

15. Desser L, Rehberger A, Paukovits W. "Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro." Cancer Biother 1994;9:253-63.

16. Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. "Bromelain treatment decreases neutrophil migration to sites of inflammation." Clin Immunol. 2008 Jul;128(1):66-74.

17. Tassman G, Zafran J, Zayon G. "A double-blind crossover study of a plant proteolytic enzyme in oral surgery." J Dent Med 1965;20:51--4.

18. Cirelli MG. "Treatment of inflammation and edema with bromelain." Delaware Med J 1962;34:159--67.

19. Brien S, Lewith G, Walker A, Hicks SM, Middleton D. "Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies." Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257.

20. Akhtar NM1, Naseer R, Farooqi AZ, Aziz W, Nazir M. "Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study." Clin Rheumatol. 2004 Oct;23(5):410-5.

21. Heinicke R, van der Wal L, Yokoyama M. "Effect of bromelain (Ananase) on human platelet aggregation." Experientia 1972;28:844--5.

22. Juhasz B, Thirunavukkarasu M, Pant R, Zhan L, Penumathsa SV, et al. "Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium." Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1365-70.

23. Rakhimov MR. "Anti-inflammatory activity of domestic papain]." Eksp Klin Farmakol. 2001 Jul-Aug;64(4):48-9.

24. Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S.  "Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan." Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347.

25. Murakami K1, Yamanaka N, Ohnishi K, Fukayama M, Yoshino M. "Inhibition of angiotensin I converting enzyme by subtilisin NAT (nattokinase) in natto, a Japanese traditional fermented food." Food Funct. 2012 Jun;3(6):674-8.

26. Kim JY, Gum SN, Paik JK, et al. "Effects of nattokinase on blood pressure: a randomized, controlled trial." Hypertens Res. 2008;31(8):1583-1588.

27. Fossati A. "Anti-inflammatory effects of seaprose-S on various inflammation models."  Drugs Exp Clin Res. 1999;25(6):263-70.

28. Moretti M, Bertoli E, Bulgarelli S, Testoni C, et al. "Effects of seaprose on sputum biochemical components in chronic bronchitic patients: a double-blind study vs placebo." Int J Clin Pharmacol Res. 1993;13(5):275-80.

29. Braga PC, Rampoldi C et al "In vitro rheological assessment of mucolytic activity induced by seaprose." Pharmacol Res 1990;22(5):611-617.

30. Bracale G, Selvetella L. "Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase." Minerva Cardioangiol. 1996 Oct;44(10):515-24.

31. Bracale.

32. Kuzan A1, Chwilkowska A, Kobielarz M, Pezowicz C, Gamian A. "Glycation of extracellular matrix proteins and its role in atherosclerosis. Postepy Hig Med Dosw (Online). 2012 Oct 29;66:804-9.

33. James Couch. "Rutin for Capillaries. USDA Yearbook of Agriculture. 1947 p711.

34. Teresita Guardia, Alejandra Ester Rotelli, et al. "Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat." Il Farmaco Volume 56, Issue 9, 1 August 2001, Pages 683--687.

35. Selloum L1, Bouriche H, Tigrine C, Boudoukha C. "Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation." Exp Toxicol Pathol. 2003 Mar;54(4):313-8.

36. Drewa G, Schachtschabel DO, Palgan K, et al. "The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice." Neoplasma 1998;45:266-71.

37. Webster RP, Gawde MD, Bhattacharya RK. "Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats." Cancer Lett 1996;109:185-91.

38. Reema Jasuja, Freda H. Passam, Daniel R. Kennedy, Robert Flaumenhaft, et al. "Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents." J Clin Invest. 2012; 122(6):2104--2113.

39. El-Akabawy G, El-Kholy W. "Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats." Ann Anat. 2014 May;196(2-3):119-28.

40. Yang M, Liu C, Jiang J, Zuo G, Lin X, et al. "Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats." BMC Complement Altern Med. 2014 May 27;14(1):174.

41. Moon M, Kim HG, Choi JG, Oh H, et al. "6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia." Biochem Biophys Res Commun. 2014 Jun 20;449(1):8-13.

42. Zeng GF1, Zhang ZY, Lu L, Xiao DQ, Zong SH, He JM. "Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats." Rejuvenation Res. 2013 Apr;16(2):124-33.

43. Duskova M, Wald M. "Orally administered proteases in aesthetic surgery." Aesthetic Plast Surg. 1999 Jan;23(1):41-4.


Start slowly. 

  • Start with 1 capsule per day at least 1 hour before or after eating.
  • Every three days, you can increase by 1 capsule until you reach a maximum of 3 capsules per day. 
  • For most people, 1-3 capsules a day is the optimum long-term dosage.
NOTE: For people who are prone to gastric sensitivity, you may follow these instructions:
  • For the first two weeks, take 1 capsule a day, at least 1 hour before eating.  Be sure to take on an empty stomach.
  • You may then increase your dosage to 2 capsules a day if desired for the next week.
  • Then if you so desire, and you are experiencing no discomfort, you can increase to 3 capsules a day, again at least 1 hour before eating.
  • For most people, 1-3 capsules a day is the optimum long term dosage.


Once you have become accustomed to the formula, however, you may choose to use it for detoxification. For detoxification, you want to slowly build to as many as 2-3 capsules, three times a day, as recommended by your health professional. You will want to run a detox program for a minimum of 30 days -- depending on the state of your health and how much damage you are trying to repair. If you experience any gastric discomfort, back your dosage down until you are comfortable again.

For detoxification (really more of an overhaul and repair of your entire body), start by doubling the maintenance dosage, then tripling it if needed, until you notice benefits, or as recommended by your health professional. You will want to run a detox program for a minimum of 30 days to as long as 12-24 months -- depending on the state of your health and how much damage you are trying to repair.

Performance Athletes:

For performance athletes, or people just interested in optimum cardiovascular health, faster recovery, and repair, you can build to (and continue on) two times the maintenance dosage, up to 6 pHi-Zymes® per day (2 capsules three times a day or 3 capsules twice a day) for as long as required. Again, if you experience any gastric discomfort, back your dosage down until you are comfortable again. For most people, taking their proteolytic enzymes in the dosage described above on a daily basis, at least 1 hour before eating is all that's needed to give you the best shot at maintaining a healthy inner environment. Since that dosage is likely to be contained in more than one capsule, it's best to spread it out over the course of the day--say one capsule three times a day, assuming the daily dosage is three capsules.

Do not take: if nursing or pregnant, if you have history of an ulcer, or if taking blood thinners. Do not take days before having elective surgery.


Can you take too much? Absolutely! As we discussed, one of the benefits of a good proteolytic enzyme formula is that it works as a natural blood thinner. But as the old saying goes, "Too much of a good thing is bad." Unlike pharmaceutical blood thinners, though, this is unlikely to ever manifest as bruises suddenly appearing all over your body. However, if your dosage goes higher than your body can handle, you will notice an increased tendency to have spontaneous nose bleeds or increased rectal bleeding if you have any hemorrhoids. If you notice any of these symptoms or have any intestinal discomfort, or discomfort of any kind, back down your dosage until the symptoms disappear.

Also, it should be noted that although supplemental proteolytic enzymes significantly decrease the risk of both ischemic and transient ischemic strokes (those caused by blood clots and that accounts for 87% of all strokes), they do, on the other hand, increase the risk of damage if you have a hemorrhagic stroke (a bleeding stroke caused by a weakened blood vessel) because clotting may take longer. Then again, proteolytic enzymes are just as likely to strengthen that blood vessel in the first place, thereby reducing your odds of having a hemorrhagic stroke at all.

Supplement Facts

Serving Size: 3 Vegetarian Capsules
Servings per Container: 150
Amount per Serving: 1500 mg
Container Size: 450 capsules
Strength: 500 mg
Click ingredient for more information
Amount Per Serving % Daily Value
Fungal Protease 300,000 HUT N/A *
Papain 24,000 TU N/A *
Bromelain 336 GDU N/A *
Fungal Pancreatin 1,200 USP N/A *
Nattokinase 540 FU N/A *
Seaprose S 15,000 U N/A *
Amylase 3,000 SKB N/A *
Lipase 192 FIP N/A *
Rutin 90 mg N/A *
Ginger Root Extract 30 mg N/A *
CMIK-pH+™ Mineral Blend¹ 240 mg N/A *
Other ingredients: Vegetable Stearate, capsule (cellulose, water)
All ingredients are either domestically sourced or selectively imported
* Daily Value Not Established

No materials used to produce this product are derived from or contain any Genetically Modified Organisms (GMOs)

Cannot Ship to Australia

¹ Contains 60 mg Potassium per Serving

All Vegan and Vegetarian Formula

Fungal Protease

Vegetarian sourced.

Protease enzymes digest protein. Taking protease enzymes with meals spares the natural pool of protease enzymes circulating in the blood so that they can continue to break down and get rid of unwanted microorganisms in the bloodstream.

Fungal protease and fungal pancreatin are names for particular strains of protease enzymes that are optimized for different pH levels. This is important as pH levels change as you move through the digestive tract. By using strains optimized for different pH's, you are assured that the proteolytic process is optimized through the entire digestive process.


Papain is one of the most widely used proteolytic enzymes, belonging to the thiol protease group. It possesses a very powerful digestive action superior to pepsin and pancreatin. Changes in intestinal alkalinity or acidity do not interfere with the unique digestive activity of papain.

Papain, one of the most powerful plant proteolytic enzymes, derived from papaya fruit, is a catalytic agent that will act in protein digestion in an acid, alkaline, or neutral medium. This is of vital importance for those with enzyme deficiency problems, as well as for those with low hydrochloric acid output in the stomach. It is important to understand that pepsin produced in the stomach to aid in protein digestion is activated only in an acid medium. This requires a healthy output of hydrochloric acid that is insufficient in most people. Since papain does not require hydrochloric acid, many people with digestive problems will be helped by daily supplementation with papain.


Bromelain is a proteolytic digestive enzyme derived from pineapple stems that can enhance absorption of protein. It may also affect protein turnover in the body including proteins found in joint tissue. The broad substrate specificity of bromelain enables the enzyme to efficiently hydrolyze most soluble proteins. This enzyme exhibits excellent performance on both animal and vegetable proteins.

Bromelain is important as an anti-inflammatory enzyme useful in post-traumatic responses and swelling and after surgery. It is also makes sense as part of an anti-aging program as it reduces tissue irritation. In addition, it helps reduce platelet aggregation, arterial plaque, and clot formation. Bromelain's most popular use has been to reduce joint inflammation in rheumatoid arthritis.

Fungal Pancreatin

Vegetarian sourced.

Protease enzymes digest protein. Taking protease enzymes with meals spares the natural pool of protease enzymes circulating in the blood so that they can continue to break down and get rid of unwanted microorganisms in the bloodstream.

Fungal protease and fungal pancreatin are names for particular strains of protease enzymes that are optimized for different pH levels. This is important as pH levels change as you move through the digestive tract. By using strains optimized for different pH's, you are assured that the proteolytic process is optimized through the entire digestive process.


Nattokinase is a potent fibrinolytic enzyme extracted and highly purified from a traditional soy-based Japanese food called Natto. Natto is a fermented cheese-like food that has been used in Japan for over 1000 years for its popular taste and as a folk remedy for cardiovascular health and vascular issues or challenges. While other soy foods contain enzymes, it is only the natto preparation that contains the specific nattokinase enzyme.

What makes nattokinase particularly potent is that it enhances the body's natural ability to fight blood clots in several different ways. Because it so closely resembles plasmin, it dissolves fibrin directly. In addition, it also enhances the body's production of both plasmin and other clot-dissolving agents, including urokinase (endogenous).

The soy is not organic but is Non - GMO.

Seaprose S

Crystalline Seaprose-S was one of the key enzymes used in the old Proteolytic Enzyme formula. It was integral to the formula because of its remarkable anti-inflammatory and anti-fluid retention activity.

In addition to reducing inflammation, it has a profound ability to reduce aches, help with mucous in the lungs and break down sputum in patients with chronic airway issues or challenges. And unlike serrapeptase, it is not affected by stomach acid so it does not require enteric coating. It is also much less upsetting to the stomach.

However, the original version of Seaprose-S was difficult to work with from a manufacturing point of view, so we switched to Endonase, which could be thought of like a less concentrated, powdered Seaprose.

Eventually, though, the manufacturer of Seaprose-S developed a more usable form of the ingredient that gave us the option of once again using it. Although Endonase worked quite well, all of the studies that validated efficacy were done with Seaprose, not Endonase. Quite simply, Jon Barron felt that having the ability to draw on those studies made it important to once again use pure, crystalline Seaprose-S in our pHi-Zymes® formula.


Amylase enzymes helps your body break down and assimilate starches and carbohydrates. Supplemental amylase can also help reduce stress.


Vegetarian sourced.

Lipase enzymes contribute to carbohydrate and fat digestive action. When added to a meal as a health supplement, lipase digests dietary fat, relieving the gallbladder, liver and the pancreas, which would otherwise need to produce the required enzymes. Protein absorption from fatty foods such as fish or seeds can be improved by incorporating supplemental lipase enzymes in the diet.


Rutin is a flavonol, a subclass of the bioflavonoids. Rutin's main benefits are that it helps strengthen capillaries and is particularly useful for those who bruise or bleed easily.

Ginger Root Extract

Ginger inhibits the COX-2 (Cyclo-Oxygenase-2) enzyme in much the same way as prescription drugs, but without the side effects—making it a powerful anti-inflammatory herb that has historically been used for arthritis and rheumatism. Multiple studies have shown that it can reduce pain and inflammation and minimize any further degradation to joint cartilage.

CMIK-pH+™ Mineral Blend¹

An optimal pH environment is crucial to the effectiveness of proteolytic enzymes. CMIK-pH+ is a proprietary blend of calcium, magnesium, ionic trace minerals, and potassium that optimizes pH – and a whole lot more.

  • First, it provides extra protection for the enzymes from stomach acid. Normally, if you take your proteolytic enzymes on an empty stomach, the acid content is fairly low so they don't suffer much damage anyway – particularly if you choose your enzymes carefully. This was one of the reasons for using Seaprose-S instead of serrapeptase in the original formula. Nevertheless, CMIK-pH+ provides that "extra level" of protection. (Note: enteric coating is a pretty marginal technology when it comes to capsules. It doesn't really protect the enzymes very well.)
  • It helps optimize the pH of the blood. In general, blood pH will vary very little to protect against death. However, minor changes in blood pH make a huge difference in proteolytic enzyme efficiency and oxygen availability. The impact of CMIK-pH+ in this regard is monumental.
  • CMIK-pH+ helps optimize the pH of all your soft tissue. Your body will do anything to keep your blood's pH in a narrow range; that means it robs Peter to pay Paul. It steals minerals and lowers pH in your soft tissue to protect your blood if your diet is too acidic. And if you eat meat, dairy, cooked grains, desserts, and most fruit, then your diet is indeed too acid. Bottom line here is that by raising soft tissue pH, you dramatically improve the ability of proteolytic enzymes to root out CIC's embedded in that soft tissue, thus relieving allergies and reducing the possibility of autoimmune conditions.
  • Finally, by providing a source of buffering minerals, CMIK-pH+ reduces the chances of osteoporosis. After all, if your body needs minerals to buffer a high acid diet, what's the biggest mineral bank in your body? Your bones! The presence of CMIK-pH+ can help offset some (or all) of that need, depending on how many pHi-Zymes®you take, so you keep minerals in your bones for strength.

Vegetable Stearate

capsule (cellulose, water)

  Do you have an Allergen Statement?
  Do you use magnesium stearate in any of your products?
  How soon can I expect to see my pH go up after taking pHi-Zymes?
  Can I take the pHi-Zymes out of their capsule?
  Do pHi-Zymes need to be kept cold?
  I am experiencing gastro-intestinal issues after using the pHi-Zymes. Is this normal?
  Can children take pHi-Zymes?
  Does it matter what time of day to take pHi-Zymes?
  Should I take both digestive enzymes and pHi-Zymes® as a regular health routine? Is one type enough?
  My feet swell when I fly, will pHi-Zymes help?
  I notice that I can breathe better on pHi-Zymes especially when I ski at higher altitudes. Could this be the formula?
  Do the pHi-Zymes contain gluten?
  You use MCU's as a unit of measure. What are MCU'S?
  What effects do pHi-Zymes have on Protein C and on coagulation?
  Is it better to take my evening dose of Triple Jointed with the pHi-Zymes or the Probiotics?
  Do your pHi-Zymes (proteolytic enzymes) list calibrated enzyme activity?
  Why aren't the pHi-Zymes Certified Organic?
  Is it true, can proteolytic enzymes enter the bloodsteam?
  Could I be killing off beneficial bacteria by taking the pHi-Zymes?
  Is Nattokinase the same as Natto?
  Is the Nattokinase in the pHi-Zymes derived from organic soy?
  Are hives a typical side effect of pHi-Zymes?
  Studies show a link of proteolytic enzymes PRSS3 to aggressive prostate cancer. Your thoughts?
  What form of calcium is used in the pHi-Zymes? Is it a rock mineral, and if so, what role does it play in the formula?
  Will pHi-Zymes raise my blood sugar levels?
  Would the pHi-Zymes help in the case of Peyronie's disease? Does it dissolve scar tissue?
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